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Synfacts 2017; 13(10): 1039
DOI: 10.1055/s-0036-1591304
DOI: 10.1055/s-0036-1591304
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Enantioselective Functionalization of Internal Alkenes
Further Information
Publication History
Publication Date:
18 September 2017 (online)
Significance
The authors developed an enantioselective introduction of electrophilic oxidants into internal alkenes by using a hetero-ene reaction. A Lewis-acid-assisted Brønsted-acid system enables this transformation with high selectivity.
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Comment
The utility of this transformation was demonstrated by the derivatization of the products to give various valuable chiral compounds. A reaction mechanism is proposed on the basis of mechanistic experiments.
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