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Synfacts 2017; 13(09): 0937
DOI: 10.1055/s-0036-1590772
DOI: 10.1055/s-0036-1590772
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Asymmetric Copper Hydride Catalyzed Coupling Reaction to Access Chiral Ketones
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. August 2017 (online)
![](https://www.thieme-connect.de/media/synfacts/201709/i_h092_s1_10-1055_s-0036-1590772.gif)
Significance
The preparation of chiral α-aryl dialkyl ketones is an important challenge for the synthesis community. The authors have developed a Cu-catalyzed enantioselective hydroacylation of α,β-unsaturated carboxylic acids with aryl alkenes.
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Comment
This direct asymmetric copper hydride catalysis is highly effective in coupling α,β-unsaturated carboxylic acids to aryl alkenes to afford the corresponding chiral α-aryl dialkyl ketones in moderate yields and with high enantioselectivities.
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![](https://www.thieme-connect.de/media/synfacts/201709/i_h092_s1_10-1055_s-0036-1590772.gif)