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Synfacts 2017; 13(04): 0419
DOI: 10.1055/s-0036-1590094
DOI: 10.1055/s-0036-1590094
Organo- and Biocatalysis
Kinetic Resolution of Primary Amines through Chiral Phosphoric Acid Catalysis
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
17. März 2017 (online)
Significance
The List group reports a kinetic resolution of primary amines by selective condensation with a 1,3-diketone. The reaction is catalyzed by a chiral BINOL-derived phosphoric acid. The method is applicable to both benzylamine derivatives and aliphatic substrates.
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Comment
The authors demonstrated an acid-catalyzed enantioselective carbonyl–amine condensation through a kinetic resolution of primary amines. There is great potential of the observed reactivity in many other transformations.
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