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Synfacts 2016; 12(10): 1071
DOI: 10.1055/s-0036-1589202
DOI: 10.1055/s-0036-1589202
Metal-Mediated Synthesis
Aromatic Hydroxylation and Amination through Deprotonative Cupration
Tezuka N, Shimojo K, Hirano K, * Komagawa S, Yoshida K, Wang C, Miyamoto K, Saito T, Takita R, Uchiyama M. * The University of Tokyo and RIKEN Center for Sustainable Resource Science, Saitama, Japan
Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration.
J. Am. Chem. Soc. 2016;
138: 9166-9171
Direct Hydroxylation and Amination of Arenes via Deprotonative Cupration.
J. Am. Chem. Soc. 2016;
138: 9166-9171
Further Information
Publication History
Publication Date:
19 September 2016 (online)
Significance
The authors report an efficient aromatic hydroxylation and amination reaction through directed ortho cupration. The method is applicable to a wide range of functionalized aromatic and heteroaromatic compounds, and shows high chemo- and regioselectivity.
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Comment
The reported reaction is the first example of an efficient, one-pot synthesis of functionalized phenols and anilines from the same substrates.
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