Subscribe to RSS
DOI: 10.1055/s-0036-1581116
Update: Imaging of Lower Extremity Infection
Publication History
Publication Date:
23 June 2016 (online)
Abstract
Pedal infection is a difficult diagnostic problem for clinicians and radiologists alike, especially in patients with diabetes. Vascular and neuropathic disease complicates the clinical picture and imaging appearance. Radiographs are usually the first examination ordered, offering an excellent overview of previous surgery, structural deformities, and neuropathic joint disease. Ultrasound and computed tomography are occasionally useful to answer specific questions. Scintigraphy has become less popular because MRI provides high sensitivity and specificity as well as detailed anatomical information. Almost all diabetic foot infections originate from a foot ulcer. Thus demonstrating communication from the skin to underlying bones, joints, tendons, and other structures is key. Careful examination of the soft tissues at MR imaging allows the radiologist to determine the extent of soft tissue infection, the presence of abscesses and septic tenosynovitis, as well as the presence of necrotic tissue. Pitfalls include fracture, neuropathic osteoarthropathy, neoplasia, and noninfectious inflammatory conditions such as gout.
-
References
- 1 Ledermann HP, Morrison WB, Schweitzer ME. MR image analysis of pedal osteomyelitis: distribution, patterns of spread, and frequency of associated ulceration and septic arthritis. Radiology 2002; 223 (3) 747-755
- 2 Morrison WB, Ledermann HP, Schweitzer ME. MR imaging of the diabetic foot. Magn Reson Imaging Clin N Am 2001; 9 (3) 603-613 , xi
- 3 Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2014: Estimates of Diabetes and Its Burden in the United States. Available at: http://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf . Accessed February 3, 2016
- 4 Chen IW, Yang HM, Chiu CH, Yeh JT, Huang CH, Huang YY. Clinical characteristics and risk factor analysis for lower-extremity amputations in diabetic patients with foot ulcer complicated by necrotizing fasciitis. Medicine (Baltimore) 2015; 94 (44) e1957
- 5 Boulton AJ. The pathway to foot ulceration in diabetes. Med Clin North Am 2013; 97 (5) 775-790
- 6 Lavery LA, La Fontaine J, Kim PJ. Preventing the first or recurrent ulcers. Med Clin North Am 2013; 97 (5) 807-820
- 7 Reekers JA. Interventional radiology in the diabetic lower extremity. Med Clin North Am 2013; 97 (5) 835-845
- 8 Lipsky BA, Aragón-Sánchez J, Diggle M , et al; International Working Group on the Diabetic Foot (IWGDF). IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes. Diabetes Metab Res Rev 2016; 32 (Suppl. 01) 45-74
- 9 Lipsky BA, Berendt AR, Cornia PB , et al; Infectious Diseases Society of America. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2012; 54 (12) e132-e173
- 10 Hingorani A, LaMuraglia GM, Henke P , et al. The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine. J Vasc Surg 2016; 63 (2, Suppl): 3S-21S
- 11 Game FL. Osteomyelitis in the diabetic foot: diagnosis and management. Med Clin North Am 2013; 97 (5) 947-956
- 12 Baker JC, Demertzis JL, Rhodes NG, Wessell DE, Rubin DA. Diabetic musculoskeletal complications and their imaging mimics. Radiographics 2012; 32 (7) 1959-1974
- 13 Donovan A, Schweitzer ME. Use of MR imaging in diagnosing diabetes-related pedal osteomyelitis. Radiographics 2010; 30 (3) 723-736
- 14 Toledano TR, Fatone EA, Weis A, Cotten A, Beltran J. MRI evaluation of bone marrow changes in the diabetic foot: a practical approach. Semin Musculoskelet Radiol 2011; 15 (3) 257-268
- 15 Roug IK, Pierre-Jerome C. MRI spectrum of bone changes in the diabetic foot. Eur J Radiol 2012; 81 (7) 1625-1629
- 16 American College of Radiology. Appropriateness criteria for suspected osteomyelitis of the foot in patients with diabetes mellitus 2012. Available at: https://acsearch.acr.org/docs/69340/Narrative/ . Accessed February 3, 2016
- 17 Glaudemans AW, Israel O, Slart RH. Pitfalls and limitations of radionuclide and hybrid imaging in infection and inflammation. Semin Nucl Med 2015; 45 (6) 500-512
- 18 Palestro CJ, Love C. Nuclear medicine and diabetic foot infections. Semin Nucl Med 2009; 39 (1) 52-65
- 19 Morrison WB, Schweitzer ME, Wapner KL, Hecht PJ, Gannon FH, Behm WR. Osteomyelitis in feet of diabetics: clinical accuracy, surgical utility, and cost-effectiveness of MR imaging. Radiology 1995; 196 (2) 557-564
- 20 Morrison WB, Schweitzer ME, Bock GW , et al. Diagnosis of osteomyelitis: utility of fat-suppressed contrast-enhanced MR imaging. [see comments]. Radiology 1993; 189 (1) 251-257
- 21 Bailey DL, Pichler BJ, Gückel B , et al. Combined PET/MRI: Multi-modality multi-parametric imaging is here: Summary Report of the 4th International Workshop on PET/MR Imaging; February 23-27, 2015, Tübingen, Germany. Mol Imaging Biol 2015; 17 (5) 595-608
- 22 Jadvar H, Colletti PM. Competitive advantage of PET/MRI. Eur J Radiol 2014; 83 (1) 84-94
- 23 Morrison WB, Schweitzer ME, Batte WG, Radack DP, Russel KM. Osteomyelitis of the foot: relative importance of primary and secondary MR imaging signs. Radiology 1998; 207 (3) 625-632
- 24 Ledermann HP, Morrison WB, Schweitzer ME, Raikin SM. Tendon involvement in pedal infection: MR analysis of frequency, distribution, and spread of infection. AJR Am J Roentgenol 2002; 179 (4) 939-947
- 25 Ledermann HP, Morrison WB, Schweitzer ME. Pedal abscesses in patients suspected of having pedal osteomyelitis: analysis with MR imaging. Radiology 2002; 224 (3) 649-655
- 26 Ledermann HP, Schweitzer ME, Morrison WB. Nonenhancing tissue on MR imaging of pedal infection: characterization of necrotic tissue and associated limitations for diagnosis of osteomyelitis and abscess. AJR Am J Roentgenol 2002; 178 (1) 215-222
- 27 American College of Radiology Committee on Drugs and Contrast Media. ACR Manual on Contrast Media 2015; v.10.1. Available at: http://www.acr.org/quality-safety/resources/contrast-manual . Accessed February 3, 2016
- 28 Ledermann HP, Morrison WB, Schweitzer ME. Is soft-tissue inflammation in pedal infection contained by fascial planes? MR analysis of compartmental involvement in 115 feet. AJR Am J Roentgenol 2002; 178 (3) 605-612
- 29 Jimenez AL, Salvo NL. Mycetoma or synovial sarcoma? A case report with review of the literature. J Foot Ankle Surg 2011; 50 (5) 569-576
- 30 Samuel S, Boopalan PR, Alexander M, Ismavel R, Varghese VD, Mathai T. Tuberculosis of and around the ankle. J Foot Ankle Surg 2011; 50 (4) 466-472
- 31 Barksfield R, Gallagher K, Pasapula C. Silent gout: an unusual presentation in diabetic neuropathy. Foot 2012; 22 (3) 264-266
- 32 Ahmadi ME, Morrison WB, Carrino JA, Schweitzer ME, Raikin SM, Ledermann HP. Neuropathic arthropathy of the foot with and without superimposed osteomyelitis: MR imaging characteristics. Radiology 2006; 238 (2) 622-631
- 33 Morrison WB, Ledermann HP. Work-up of the diabetic foot. Radiol Clin North Am 2002; 40 (5) 1171-1192
- 34 Morrison WB, Ledermann HP, Schweitzer ME. MR imaging of inflammatory conditions of the ankle and foot. Magn Reson Imaging Clin N Am 2001; 9 (3) 615-637 , xi–xii
- 35 Mirigliano E, LaTour R, Abramczuk JW. Squamous cell carcinoma of the foot mimicking osteomyelitis: a case report. J Foot Ankle Surg 2011; 50 (4) 480-485