Synfacts 2016; 12(09): 0911
DOI: 10.1055/s-0035-1562556
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Molecular Knot Inducing Allosteric Control of Catalysis

Contributor(s):
Timothy M. Swager
,
Constantin-Christian A. Voll
Marcos V, Stephens AJ, Jaramillo-Garcia J, Nussbaumer AL, Woltering SL, Valero A, Lemonnier J.-F, Vitorica-Yrezabal IJ, Leigh DA * University of Manchester, UK
Allosteric Initiation and Regulation of Catalysis with a Molecular Knot.

Science 2016;
352: 1555-1559
Further Information

Publication History

Publication Date:
18 August 2016 (online)

 

Significance

Molecular knots are found in nature and, although synthetic knots have been synthesized, the benefits of knotted molecules remain unclear. In this report, the authors synthesize a molecular knot, perform a metal exchange, and are able to establish a catalytic cycle that can be allosterically initiated and regulated.


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Comment

The synthesis of the molecular knot is high yielding and both removal of metals and exchange is possible without uncoiling of the structure. The authors show catalytic hydrolysis, ­Michael addition, and Diels–Alder reactions.


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