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Synthesis 2016; 48(19): 3331-3338
DOI: 10.1055/s-0035-1562514
DOI: 10.1055/s-0035-1562514
paper
Synthesis of β-Hydroxynaphthoate Derivatives from Ketodioxinones via Benzyne Acyl-Alkylation and Aldol Condensation Cascade
Further Information
Publication History
Received: 02 June 2016
Accepted after revision: 16 June 2016
Publication Date:
19 July 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201619/lookinside/thumbnails/ss-2016-c0400-op_10-1055_s-0035-1562514-1.jpg)
Dedicated to the memory of Prof. Jean F. Normant
Abstract
A variety of highly functionalized β-hydroxynaphthoate derivatives are prepared by a two-step protocol: (1) acyl-alkylation of benzynes with ketodioxinones and (2) intramolecular aldol condensation. The substitution pattern of the products is related to polycyclic natural products derived from the type-II polyketide biosynthesis.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562514.
- Supporting Information
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