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Synthesis 2016; 48(19): 3232-3240
DOI: 10.1055/s-0035-1562443
DOI: 10.1055/s-0035-1562443
paper
6-endo-dig Cycloisomerization of N-Propargyl Aminoquinoxalines: A New Route to 1,4,8-Triazaphenanthrenes
Further Information
Publication History
Received: 13 May 2016
Accepted after revision: 06 June 2016
Publication Date:
07 July 2016 (online)
![](https://www.thieme-connect.de/media/synthesis/201619/lookinside/thumbnails/ss-2016-c0344-op_10-1055_s-0035-1562443-1.jpg)
This paper is dedicated in the memory of Prof Jean F. Normant, a great mentor and a wonderful person.
‡ S.V. and G.L.D. contributed equally to this work.
Abstract
We report the preparation of novel 1,4,8-triazaphenanthrenes and show that the target compounds are efficiently obtained from the corresponding 6-aminoquinoxalines after N-propargylation followed by copper-catalyzed 6-endo-dig cycloisomerization and aromatization. The cyclization was found to be completely regioselective.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035–1562443.
- Supporting Information
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