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Synfacts 2016; 12(06): 0619
DOI: 10.1055/s-0035-1562214
DOI: 10.1055/s-0035-1562214
Metal-Mediated Synthesis
Enantioselective Arylation of Pyridine
Lutz JP, Chau ST, Doyle AG * Princeton University, USA
Nickel-Catalyzed Enantioselective Arylation of Pyridine.
Chem. Sci. 2016;
DOI: 10.1039/C6SC00702C.
Nickel-Catalyzed Enantioselective Arylation of Pyridine.
Chem. Sci. 2016;
DOI: 10.1039/C6SC00702C.
Further Information
Publication History
Publication Date:
17 May 2016 (online)
Significance
Doyle and co-workers report the enantioselective nickel-catalyzed arylation of pyridine by cross-coupling of various arylzinc reagents with pyridinium ions generated in situ. The reaction proceeds under mild conditions and the corresponding products are afforded in good yields and with very high enantioselectivity.
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Comment
Additionally, various transformations of the 2-aryl-1,2-dihydropyridines with little or no loss of ee are shown, demonstrating that this method is a valuable tool for the synthesis of chiral building blocks.
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