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Synthesis 2016; 48(18): 3057-3064
DOI: 10.1055/s-0035-1561457
DOI: 10.1055/s-0035-1561457
paper
Three-Component Reaction for the Convenient Synthesis of Functionalized 3-{1-[2-(1H-Indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones
Further Information
Publication History
Received: 26 January 2016
Accepted after revision: 27 April 2016
Publication Date:
07 June 2016 (online)
Abstract
A simple synthetic protocol was developed for the efficient synthesis of functionalized 3-{1-[2-(1H-indol-3-yl)ethyl]-4,5,6,7-tetrahydro-1H-indol-3-yl}indolin-2-ones in high yield via three-component reaction of tryptamine, dimedone, and 3-phenacylideneoxindoles in refluxing acetonitrile with p-toluenesulfonic acid as catalyst.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561457. Included are 1H and 13C NMR spectra for all new compounds.
- Supporting Information
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