Synthesis 2016; 48(09): 1407-1413
DOI: 10.1055/s-0035-1561375
paper
© Georg Thieme Verlag Stuttgart · New York

Two Novel and Simple Approaches to ‘CD45 Protein Tyrosine Phosphatase Inhibitor’ (Z)-Pulchellalactam and Derivatives

E. Anselmi
a   Laboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France   Email: mohamed.abarbri@univ-tours.fr
,
K. Cherry
b   Laboratoire de Matériaux, Catalyse, Environnement et Méthodes Analytiques (MCEMA), Université Libanaise, Faculté des Sciences, Section I, Hadath, Lebanon
,
C. Maaliki
a   Laboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France   Email: mohamed.abarbri@univ-tours.fr
,
S. Inack Ngi
a   Laboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France   Email: mohamed.abarbri@univ-tours.fr
,
A. Duchêne
a   Laboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France   Email: mohamed.abarbri@univ-tours.fr
,
J. Thibonnet
a   Laboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France   Email: mohamed.abarbri@univ-tours.fr
,
M. Abarbri*
a   Laboratoire d’Infectiologie et Santé Publique, UMR 1282 Université François Rabelais/INRA, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France   Email: mohamed.abarbri@univ-tours.fr
› Author Affiliations
Further Information

Publication History

Received: 24 November 2015

Accepted after revision: 14 January 2016

Publication Date:
16 February 2016 (online)


Abstract

Two novel routes to the naturally occurring CD45 protein tyrosine phosphatase inhibitor, (Z)-pulchellalactam, and its derivatives are reported in two steps starting from dienoic acids through electrophilic cyclisation. This methodology proceeds regio- and stereoselectively, and can be used to design a library of synthetic pulchellalactam analogues.

Supporting Information

 
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