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Synlett 2015; 26(20): 2801-2805
DOI: 10.1055/s-0035-1560521
DOI: 10.1055/s-0035-1560521
cluster
Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine
Further Information
Publication History
Received: 28 July 2015
Accepted after revision: 13 October 2015
Publication Date:
29 October 2015 (online)
![](https://www.thieme-connect.de/media/synlett/201520/lookinside/thumbnails/st-2015-s0585-c_10-1055_s-0035-1560521-1.jpg)
Dedicated to the memory of Prof. Tsutomu Katsuki for his enormous contribution to synthetic organic chemistry and encouragement to us.
Abstract
The diversity-oriented doubling strategy, which generates two 12-arylbenzoacridines from a single triarylmethanol precursor was developed to construct a library of drug candidates for the identification of biologically active compounds. Exploration of this 12-arylbenzoacridine library furnished a 4′-OH derivative as an estrogenic compound.
Key words
arenes - cyclization - heterocycles - medicinal chemistry - aminotriarylmethanol - 12-arylbenzoacridine - diversity-oriented doubling strategy - estrogenic activitySupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560521.
- Supporting Information
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For selected recent reviews, see:
For example, see:
For example, see:
For example, see:
For examples of selective estrogen receptor modulators (SERMs) therapeutically used for menopausal disorders (e.g., osteoporosis), see: