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Synthesis 2015; 47(23): 3733-3740
DOI: 10.1055/s-0035-1560184
DOI: 10.1055/s-0035-1560184
paper
Synthesis of 5H-Pyrrolo[3,4-b]pyrazine-Based Peptidomimetics
Further Information
Publication History
Received: 28 May 2015
Accepted after revision: 30 July 2015
Publication Date:
16 September 2015 (online)
Dedicated to Professor Mykhailo Yu. Kornilov on the occasion of his retirement
Abstract
A range of 5H-pyrrolo[3,4-b]pyrazine-based peptidomimetics were designed, and their efficient synthesis starting from 5-imino-5H-pyrrolo[3,4-b]pyrazin-7-amine by subsequent interaction with N-protected amino acid hydrazides and amino acid esters with N,N-carbonyldiimidazole as the coupling agent was elaborated.
Supporting Information
- for this article that contains the copies of NMR spectra of all compounds and the details of H/D exchange, concentration and temperature dependence studies is available online at http://dx.doi.org/10.1055/s-0035-1560184.
- Supporting Information
-
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