Giant Aneurysmal Bone Cyst of the Anterior Cranial Fossa and Paranasal Sinuses Presenting in Pregnancy: Case Report and Literature Review

Abstract

Background and Purpose Aneurysmal bone cysts (ABCs) rarely involve the cranium and have seldom been reported in pregnancy.

Clinical Presentation We describe a case of a 28-year-old woman who presented at 37 weeks of gestation with 3 months of gradually worsening vision, 10 months of proptosis, and restricted ocular motility on the left. Brain imaging revealed a multicystic enhancing mass measuring 5.9 × 5.3 × 3.7 cm, centered on the cribriform plate on the left, extending into the anterior cranial fossa superiorly as well as the left nasal cavity, maxillary, sphenoid, and frontal sinuses. Her clinical course is described in detail; 3-month postoperative imaging demonstrated no residual mass.

Conclusion A literature review revealed five previous cases of ABCs associated with pregnancy. We report a rare case of a giant ABC of fibrous dysplasia involving the paranasal sinuses and anterior cranial fossa. We postulate on the possible influence of pregnancy on the clinical course.

Keywords

aneurysmal bone cyst - pregnancy - skull base

Introduction

Jaffe and Lichtenstein provided the first description of an aneurysmal bone cyst (ABC) as a distinct pathologic entity in a series of 19 cases published in 1942.[1] The most common location was in long bones, and most cases presented between early childhood and adolescence.[1] Subsequently, these initial observations were confirmed.[2] A review of 150 patients with ABCs by Mankin et al showed predominant involvement of the tibia, fibula, and femur, and a mean age of 18 years.[2] Involvement of the skull, however, is rare, representing only 3 to 6% of all cases.[3]

We report a rare case of a giant ABC arising in the setting of fibrous dysplasia involving the paranasal sinuses and anterior cranial fossa. We also describe details of gross total surgical resection and clinical course. Epidemiology, typical presentation, imaging findings, histopathology, treatment options, and clinical outcomes of cranial ABCs are also reviewed. The effect of pregnancy on lesion growth is discussed.

Case Presentation

History and Examination

A 28-year-old woman presented at 37 weeks of gestation with 3 months of gradually worsening vision, 10 months of proptosis, and restricted ocular motility on the left. She described onset of left maxillary sinus fullness and pain several months prior to pregnancy and a single episode of epistaxis 2 months prior to presentation. On examination, the patient was found to have anosmia, a left relative afferent papillary defect, lack of light perception, and inability to count fingers with the left eye, a left abducens palsy, left-sided epiphora, bilateral nasal obstruction, and significant proptosis of the left eye. Ophthalmologic examination revealed ability to count fingers at 6 inches only in the left eye; visual acuity was 20/25 in the right eye. Visual field testing demonstrated total superior and inferior temporal, superior nasal, and inferior nasal deficits on the left. She underwent an uncomplicated augmented labor with vacuum assistance the day following presentation, resulting in a healthy infant. Further investigations were then initiated.

Magnetic Resonance Imaging

Brain imaging revealed a multicystic enhancing mass measuring 5.9 × 5.3 × 3.7 cm, centered on the cribriform plate on the left, extending into the anterior cranial fossa superiorly as well as the left nasal cavity, maxillary, sphenoid, and frontal sinuses. There were fluid-fluid levels. Mass effect was exerted on the optic nerves and chiasm, as well as the left frontal lobe, with 1 cm midline shift to the right ([Fig. 1]).

Fig. 1 Preoperative T1 gadolinium-enhanced magnetic resonance imaging demonstrating the lesion of interest. (A) Sagittal. (B) Coronal. (C) Axial. Note the prominent fluid-fluid levels and multiple internal septations.

Cerebral Angiography

We performed cerebral angiography to ascertain lesion vascularity for potential preoperative embolization. Interestingly, there was no significant vascular supply to the lesion from either the internal or external carotid circulations. Hence embolization was not performed.

Operation

The patient underwent bifrontal craniotomy with cranialization of bilateral frontal sinuses and a gross total mass resection. Intraoperatively, the mass was eccentric to the left, primarily involving the cribriform plate and the superomedial aspect of the orbital roof and wall. The mass was completely extradural, and the bone had undergone significant remodeling with lateral displacement of the left orbit. A very thin eggshell-like osseous capsule was carefully dissected from the dura. The mass itself contained several cystic areas containing dark motor oil–like fluid consistent with old blood products. The planum sphenoidale was eroded and elevated, and the bony roof of the optic canal had been replaced.

Attachment of the dura to the crista galli was ligated and divided. The resection extended down through the cribriform plate, the ethmoids, and the maxillary and sphenoid sinuses. The bilateral superior turbinates were resected due to tumor involvement, and the posterior third of the superior nasal septum was also resected due to replacement by the lesion. Upon gross total resection of the mass, the optic chiasm and optic nerves, as well as the sella, had been extradurally skeletonized, and the left orbit had been unroofed medially and superiorly ([Fig. 2]).

Fig. 2 Intraoperative photograph following complete resection of lesion.

Reconstruction of the defect was accomplished using a large vascularized pericranial graft harvested at the time of approach. The pericranium was laid back to the origin of the bony defect abutting the location of the anterior clinoids, and it was anchored using 3-mm screws to the lateral sphenoid wings. The bifrontal craniotomy flap was plated and replaced in normal anatomical alignment.

Postoperative Course

The patient had an uneventful recovery and was discharged on the postoperative day 10. At the 3-month follow-up, her proptosis had resolved, and vision was 20/25 (right eye) and 20/800 (left eye). Neurologic examination was normal, and the patient reported she was feeling well. Imaging revealed no residual/recurrent tumor ([Fig. 3]).

Fig. 3 The 3-month postoperative T1 gadolinium-enhanced magnetic resonance image demonstrating complete resection of lesion.

Pathology

The resected mass lesion material consisted of multiple fragments of red tan soft tissue with some cartilage and bone. Microscopically ([Fig. 4]), the lesion consisted of multiple blood-filled spaces lined by fibrous septae composed of loose fibrous tissue containing a uniform population of plump fibroblasts admixed with scattered osteoclast-like giant cells. The fibrous septae were rich in capillaries and had foci of chronic inflammatory infiltrates and reactive bone. This histomorphology is characteristic of an ABC. There was a benign fibro-osseous proliferation with irregular curvilinear profiles of the woven bone in the background of the ABC. Osteoblastic rimming was very inconspicuous, putting fibrous dysplasia and ossifying fibroma in the histologic differential diagnosis for the background process. Fragments of unremarkable sinus mucosa accompanied resection material from the left frontal and left maxillary sinuses. Immunohistochemistry for estrogen (ER) and progesterone receptors (PR) did not demonstrate nuclear staining of any cell populations.

Fig. 4 (A) Low-power view, variable size blood-filled spaces divided by fibrous septae. (B) Higher power view, loose fibrous tissue containing multiple capillaries and monotonous population of plump fibroblasts. (C) Small group of osteoclast-like giant cells. (D) Background of benign fibro-osseous proliferation (fibrous dysplasia versus ossifying fibroma).

Literature Review

The effect of pregnancy and associated hormonal changes on the growth of ABCs is relatively unknown. Cataltepe et al[4] reported a case of an ABC of the frontal bone of a 28-year-old woman who presented with localized swelling during her first pregnancy. After delivery, the lesion remained quiescent. One year later, she again became pregnant, and during this pregnancy, there was rapid lesion growth. The ABC was resected without complication postdelivery. The authors hypothesize that growth of the ABC during pregnancy may be attributable to increased hematopoietic activity of pregnancy, increased cortisol secretion during pregnancy and its inhibition of normal osteogenesis through vitamin D antagonism, and/or placental secretion of human placental lactogen (HPL), which has a growth hormone–like effect. Westbury et al[5] reported a case of a mandibular central giant cell granuloma with ABC change exhibiting rapid growth during pregnancy. Interestingly, the multinucleated cells of the central giant cell granuloma were positive for ERs. The authors submit that this may have been a contributing factor in the lesion's rapid growth in pregnancy. Mintz et al[6] described a patient with Albright syndrome and polyostotic fibrous dysplasia. During pregnancy, she went on to develop ABCs within severe preexisting fibrous dysplasia in the humerus and acromion. The authors ascribed the development of the ABCs to hemodynamic and hormonal factors related to pregnancy. Two other ABC cases associated with pregnancy, one of the ethmoid and one of the ileum, were reported, but neither was associated with documented rapid growth or development in pregnancy.[7] [8]

Discussion

ABCs are uncommon lesions, accounting for 1 to 2% of all primary bone tumors.[9] In their review, Mankin et al[2] reported on 150 ABC cases; mean age at presentation was 18 years, with females slightly more commonly affected.[2] Lesions involving the skull are rare, comprising only 3 to 6% of all ABCs.[3] ABCs have been reported to involve both the neurocranium (ethmoidal and/or sphenoidal,[10] [11] [12] [13] [14] [15] [16] [17] [18] temporal,[19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] occipital,[21] [31] [32] [33] [34] [35] parietal,[36] [37] frontal,[12] [38] [39] [40] [41]) and viscerocranium (mandible,[42] maxilla,[43] and zygoma[44]).

Clinically, presentation depends on location. Lesions of the convexity usually present with localized swelling that may be painful or painless.[45] Neurologic deficits are seldom present. Lesions involving the skull base are more likely to present with focal neurologic deficits. These can include anosmia,[10] [12] visual deficits,[12] [13] [17] [46] facial numbness,[30] ocular motility deficits and diplopia,[18] [40] hearing loss,[19] [23] [30] facial weakness,[23] [24] [30] jugular foramen syndrome,[47] and ataxia.[33] ABCs may also present with symptoms and signs of elevated intracranial pressure,[21] [23] [48] spontaneous intracranial hemorrhage,[20] [49] seizure,[29] [50] obstructive hydrocephalus,[34] proptosis,[10] [14] [16] [17] [40] epistaxis and nasal obstruction,[11] [12] [15] [17] otalgia,[30] otitis media,[24] and ear mass.[27]

Computed tomography (CT) findings include widening of diploic spaces, osseous expansion, narrowing of vascular and neural foramina, ground-glass opacity, and contrast enhancement.[31] Fluid levels are present on CT in 35% of cases, with increased attenuation of the dependent level.[40]

Magnetic resonance imaging (MRI) is more likely than CT to show fluid levels, particularly on T1-weighted images.[40] Although fluid levels are characteristic of ABCs, they may be observed in other lesions of the head and neck including cystic hygroma, soft tissue cavernous hemangioma, and simple bone cyst.[51] Other MRI findings include multiple internal septations, a T1 and T2 hypointense rim demarcating the lesion from surrounding structures, and, on T1-weighted images, multiple internal lobulations with varying intensities[18] due to blood degradation products of differing ages.[40] A soap bubble appearance may also be appreciated, due to the presence of diverticula, small cysts projected from larger cysts.[40]

Cerebral angiography may show a significant tumor blush, usually on injection of the external carotid. The center of the lesion tends to be avascular; the periphery is highly vascularized. Alternatively, the lesion may not demonstrate any blush but only displacement of the surrounding normal vessels.[52]

Pathogenesis of ABCs is somewhat controversial. They are often classified as primary and secondary, with primary lesions appearing in isolation and secondary lesions appearing in the setting of another antecedent osseous lesion or as a result of trauma. The most common such antecedent lesion is giant cell tumor. Other lesions include chondroblastoma, osteoblastoma, osteosarcoma, nonossifying fibroma, fibromyxoma, and fibrous dysplasia.[46] Alternatively, it has been postulated that ABCs always arise as a secondary phenomenon in an antecedent lesion. The antecedent lesion undergoes involutional change, “initiates an intraosseous arteriovenous malformation and thereby creates, via hemodynamic forces, a secondary reaction of bone, which we know as an aneurysmal bone cyst.”[53] An antecedent lesion can be identified histopathologically in about a third of ABCs, and it is possible that in cases in which no lesion is identified, it has been completely obliterated by the ABC.[54]

In terms of pathology diagnosis, it can be important to differentiate primary from secondary ABCs. Many primary ABCs have a t(16;17)(q22;p13) translocation.[43] This translocation leads to a fusion of the cadherin 11 gene (CDH11) with ubiquitin specific peptidase 6/Tre-2 (USP6) gene. Other known fusion partners for USP6 are TRAP150, ZNF9, OMD, and COL1A1.[41] This translocation is present only in fibroblasts and not seen in inflammatory cells, endothelial cells, metaplastic bone-associated osteoblasts, and multinucleated osteoclast-like giant cells. Secondary ABCs arising in the background of another proliferative process (as in this case) do not show this particular translocation.[1] There are other less frequent translocations (e.g., t(X;9)(q26;q32)) that can be seen in some ABCs.[28]

Another clinically important entity in the differential diagnosis is telangiectatic osteosarcoma. Low-power microscopic appearance is similar to an ABC, but telangiectatic osteosarcoma is a high-grade sarcoma and usually shows frank anaplasia at high power. Giant cell reparative granuloma, giant cell tumor, chondroblastoma, osteoblastoma, and combination of unicameral solitary bone cyst with post fracture changes are other more benign entities in the differential diagnosis of primary ABC.[14] Overall, immunohistochemistry is not helpful in the diagnosis of ABC. Fibroblasts are positive for vimentin. Cytokeratins, EMA, MDM2, and CDK4 are negative.

Gross total resection is the treatment of choice for cranial ABC.[52] This may be more difficult to achieve when the lesion is large or when it involves the cranial base. Preoperative endovascular embolization is a useful adjunct if the tumor is highly vascular. Embolization is rarely used as a stand-alone treatment for lesions that are not surgically accessible.[55] Radiotherapy has been used in some cases, but due to high recurrence rates (> 30%) and risk of sarcomatous degeneration, this treatment is reserved for unresectable or recurrent lesions[3] and very seldom used. Gross total resection is generally curative, whereas subtotal resection or curettage has a recurrence rate of up to 50%.[3]

In the case we present, it is quite possible that the lesion exhibited rapid growth in pregnancy. Prior to her becoming pregnant, the patient experienced maxillary fullness and sinus pain. However, significant and rapidly progressive new symptoms arose during pregnancy including visual loss, proptosis, decreased ocular motility, and epistaxis. The tumor specimen was negative for ER and PR; therefore these hormones of pregnancy are unlikely to have played a role in rapid growth. However, increased hematopoiesis, increased cortisol, and increased HPL in pregnancy may have contributed to rapid growth of this patient's ABC.

Conclusion

ABCs of the skull are rare. They may exhibit rapid growth in pregnancy, although the reasons for this are not well known. This possibility should be taken into consideration when providing preconception counseling for patients with known ABCs, particularly of the skull base. Clinical presentation depends on location, and lesions can often be identified preoperatively based on characteristic imaging findings. Gross total resection is the treatment modality of choice. Familiarity with skull base techniques is essential to resect lesions safely and completely arising in these locations.

Acknowledgments

The authors thank Shirley McCartney, PhD, and Andy Rekito, MS, for editorial assistance and figure preparation, respectively.

• References

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