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DOI: 10.1055/s-0035-1550049
Habitual Physical Activity, Sedentary Behaviour and Bone Health in Rheumatoid Arthritis
Publication History
accepted after revision 14 April 2015
Publication Date:
10 August 2015 (online)
![](https://www.thieme-connect.de/media/sportsmed/201512/lookinside/thumbnails/4744_10-1055-s-0035-1550049-1.jpg)
Abstract
Associations between habitual physical activity levels and bone health in rheumatoid arthritis (RA) were assessed. Twenty nine female patients with RA were assessed for bone mineral density (BMD), and classified as having low or normal hip BMD. Habitual physical activity levels were assessed using accelerometry, and disease activity was assessed using the Clinical Disease Activity Index (CDAI). Twenty one patients had normal bone mass, while 8 had low bone mass. There was no difference in age in the normal bone mass group (51(8)) compared to the low bone mass group (57(12)), p=0.19. Patients with normal bone mass spent on average 2 h less per day in sedentary activity (65(4)% vs. 73(2)%, p<0.01), over 70 min more time in light activity (23(1)% vs. 18(2)%, p<0.01), and over 50 min more in moderate activity per day (12(3)% vs. 8(2)%, p<0.01) than did patients with low bone mass, independently of disease activity or duration. Patients with normal bone mass broke up their sedentary time more frequently per day (72(21) vs. 53(18) times per day, p=0.03). The results of this study indicate that higher habitual activity levels may be protective of bone health in patients with RA, and should be encouraged.
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References
- 1 Armstrong MEG, Spencer EA, Cairns BJ, Banks E, Pirie K, Green J, Wright FL, Reeves GK, Beral V. Body mass index and physical activity in relation to the incidence of hip fracture in postmenopausal women. J Bone Miner Res 2011; 26: 1330-1338
- 2 Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-324
- 3 Bailey CA, Brooke-Wavell K. Exercise for optimising peak bone mass in women. Proc Nutr Soc 2008; 67: 9-18
- 4 Chang R, Roubenoff R, Mayer J, Brandt KD, Schanberg LE. Work group recommendations: 2002 Exercise and physical activity conference, St Louis, Missouri. Arthritis Rheum 2003; 49: 280
- 5 Cooney JK, Law R-J, Matschke V, Lemmey AB, Moore JP, Ahmad Y, Jones JG, Maddison P, Thom JM. Benefits of exercise in rheumatoid arthritis. J Aging Res 2011 Article ID 681640
- 6 Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel J, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M. Sarcopenia: European consensus on definition and diagnosis: Report of the European working group on sarcopenia in older people. Age Ageing 2010; 39: 412-423
- 7 Da Rocha O, Batista A, Maesta N, Burini RC, Laurindo I. Sarcopenia in rheumatoid cachexia: definition, mechanisms, clinical consequences and potential therapies. Bras J Rheumatol 2009; 49: 288-301
- 8 De Laet C, Kanis JA, Odén A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ, Meunier PJ, Pols HAP, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int 2005; 16: 1330-1338
- 9 Deodhar AA, Woolf AD. Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Br J Rheumatol 1996; 35: 309-322
- 10 Ellingson L, Colbert L, Cook D. Physical activity is related to pain sensitivity in healthy women. Med Sci Sport Exerc 2012; 44: 1401-1406
- 11 Figueiredo CP, Domiciano DS, Lopes JB, Caparbo VF, Scazufca M, Bonfá E, Pereira RMR. Prevalence of sarcopenia and associated risk factors by two diagnostic criteria in community-dwelling older men: the São Paulo Ageing & Health Study (SPAH). Osteoporos Int 2014; 25: 589-596
- 12 Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, Farzadfar F, Riley LM, Ezzati M. National, regional, and global trends in body-mass index since 1980: systemic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011; 12: 557-567
- 13 Geraci A, Maria S. Osteoporosis in rheumatoid arthritis in Insights and perspectives in rheumatology. Dr. Harrison A. (Ed.). InTech. 2006: 75-93
- 14 Gough AK, Lilley J, Eyre S, Holder RL, Emery P. Generalised bone loss in patients with early rheumatoid arthritis. Lancet 1994; 344: 23-27
- 15 Hagberg J, Zmuda J, McCole S, Rodgers KS, Ferrell RE, Wilund KR, Moore GE. Moderate physical activity is associated with higher bone mineral density in postmenopausal women. J Am Geriatr Soc 2001; 49: 1411-1417
- 16 Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK. Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum 2000; 43: 522-530
- 17 Häkkinen A, Sokka T, Kautiainen H, Kotaniemi A, Hannonen P. Sustained maintenance of exercise-induced muscle strength gains and normal bone mineral density in patients with early rheumatoid arthritis: a 5-year follow-up. Ann Rheum Dis 2004; 63: 910-916
- 18 Häkkinen A, Sokka T, Kotaniemi A, Hannonen P. A randomized two-year study of the effects of dynamic strength training on muscle strength, disease activity, functional capacity, and bone mineral density in early rheumatoid arthritis. Arthritis Rheum 2004; 44: 515-522
- 19 Harris DJ, Atkinson G. Ethical standards in sports and exercise science research: 2014 update. Int J Sports Med 2013; 34: 1025-1028
- 20 Kroot EJ, Nieuwenhuizen MG, de Waal Malefijt MC, van Riel PL, Pasker-de Jong PC, Laan RF. Change in bone mineral density in patients with rheumatoid arthritis during the first decade of the disease. Arthritis Rheum 2001; 44: 1254-1260
- 21 Laan M. Bone mineral density in patients with recent onset rheumatoid arthritis: influence of disease activity. Ann Rheum Dis 1993; 52: 21-26
- 22 Leslie WD, Adler R, El-Hajj Fuleihan G, Hodsman AB, Kendler DL, McClung M, Miller PD, Watts NB. Application of the 1994 WHO classification to populations other than postmenopausal Caucasian women: the 2005 ISCD Official Positions. J Clin Densitom 2006; 9: 22-30
- 23 Leslie WD, Lix LM, Tsang JF, Caetano PA. Single-site vs multisite bone density measurement for fracture prediction. Arch Intern Med 2007; 167: 1641-1647
- 24 Lodder MC, de Jong Z, Kostense PJ, Molenaar ETH, Staal K, Voskuyl E, Hazes JMW, Dijkmans BAC, Lems WF. Bone mineral density in patients with rheumatoid arthritis: relation between disease severity and low bone mineral density. Ann Rheum Dis 2004; 63: 1576-1580
- 25 Looker A, Borrud LG, Hughes JP. Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: United States. Vital Heal Stat 2012; 11: 1-141
- 26 Mikuls TR, Saag KG, Curtis J, Bridges L, Alarcon GS, Westfall A, Lim SS, Smith EA, Jonas BL, Moreland LW. and the CLEAR Investigators . Prevalence of osteoporosis and osteopenia among African Americans with early rheumatoid arthritis: The impact of ethnic-specific normative data. J Natl Med Assoc 2005; 97: 1155-1560
- 27 Muir JM, Ye C, Bhandari M, Adachi JD, Thabane L. The effect of regular physical activity on bone mineral density in post-menopausal women aged 75 and over: a retrospective analysis from the Canadian multicentre osteoporosis study. BMC Musculoskelet Disord 2013; 14: 1-9
- 28 Nelson ME, Rejeski WJ, Blair SN, Duncan PW, Judge JO, King AC, Macera CA, Castaneda-Sceppa C. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 2007; 39: 1435-1445
- 29 Newman AB, Kupelian ÃV, Visser ÃM, Simonsick E, Goodpaster B, Nevitt ÃM, Kritchevsky SB, Tylavsky FA, Rubin SM. Sarcopenia: Alternative definitions and associations with lower extremity function. J Am Geriatr Soc 2003; 51: 1602-1609
- 30 Owen N, Healy GN, Matthews CE, Dunstan DW. Too much sitting: the population health science of sedentary behavior. Exerc Sport Sci Rev 2010; 38: 105-113
- 31 Pate RR, O’Neill JR, Lobelo F. The evolving definition of “sedentary”. Exerc Sport Sci Rev 2008; 36: 173-178
- 32 Prioreschi A, Hodkinson B, Avidon I, Tikly M, McVeigh JA. The clinical utility of accelerometry in patients with rheumatoid arthritis. Rheumatology 2013; 26: 1-7
- 33 Puoane T, Steyn K, Bradshaw D, Laubshcer R, Fourie J, Lambert V, Mbananga N. Obesity in South Africa: the South African demographic and health survey. Obes Res 2002; 10: 1038-1048
- 34 Tudor-locke C, Brashear MM, Johnson WD, Katzmarzyk PT. Accelerometer profiles of physical activity and inactivity in normal weight, overweight, and obese U.S. men and women. Int J Behav Nutr Phys Act 2010; 7: 60