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Planta Med 2015; 81(07): 600-605
DOI: 10.1055/s-0035-1545882
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Bisbenzylisoquinoline Alkaloids from the Roots of Cyclea tonkinensis

Jian-zhong Wang
West China College of Pharmacy, Sichuan University, Chengdu, P. R. China
,
Jing Liao
West China College of Pharmacy, Sichuan University, Chengdu, P. R. China
,
Wen-long Xu
West China College of Pharmacy, Sichuan University, Chengdu, P. R. China
,
Xiao-bing Chen
West China College of Pharmacy, Sichuan University, Chengdu, P. R. China
› Author Affiliations
Further Information

Publication History

received 09 July 2014
revised 25 February 2015

accepted 26 February 2015

Publication Date:
09 April 2015 (online)

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Abstract

Cissampentine A (1), an enantiomer of cissampentin, three new cycleatjehenine-type bisbenzylisoquinoline alkaloids, cissampentine B–D (2–4), and five known alkaloids were isolated from the roots of Cyclea tonkinensis. Their structures were established by interpretation of NMR, high-resolution ESI-MS data, and CD spectra. In vitro studies indicated that compounds 1 and 4 exhibited cytotoxicity against the HCT-8 tumor cell line (IC50 values of 8.97 and 9.73 µM, respectively), and compound 4 was also active against the Bel-7402 tumor cell line (IC50 value of 5.36 µM).

Key words

Cyclea tonkinensis - Menispermaceae - bisbenzylisoquinoline alkaloid - cissampentine A - cissampentine B - cissampentine C - cissampentine D - cytotoxic activity

Supporting Information

 

  • References

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