Download PDF
Thorac Cardiovasc Surg 2015; 63(07): 624-627
DOI: 10.1055/s-0035-1545260
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Use of del Nido Cardioplegia in Adult Cardiac Surgery

Rajesh Ramanathan
1   Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States
,
Dan W. Parrish
1   Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States
,
Trygve K. Armour
1   Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States
,
Derek R. Brinster
2   Department of Cardiac Surgery, Lenox Hill Hospital, North Shore-Long Island Jewish Health System, New York, New York, United States
› Author Affiliations
Further Information

Publication History

28 April 2014

18 December 2014

Publication Date:
05 March 2015 (online)

    Permissions and Reprints All articles of this category

Abstract

Background del Nido cardioplegia was developed to protect pediatric hearts, and similar to pediatric hearts, older adult hearts tolerate ischemia–reperfusion poorly. This study investigates the feasibility of del Nido cardioplegia as an alternative to conventional Buckberg cardioplegia in adult cardiac surgery.

Methods A total of 142 adult patients undergoing cardiopulmonary bypass with del Nido cardioplegia and conventional Buckberg cardioplegia were retrospectively reviewed.

Results Fewer doses of cardioplegia and fewer defibrillations were noted with del Nido cardioplegia, and there were no significant differences in incidence of postoperative events.

Conclusion del Nido cardioplegia may be a feasible alternative to conventional Buckberg cardioplegia.

Keywords

cardiac surgery - cardiopulmonary bypass - hypothermia - ischemia–reperfusion - minimally invasive surgery

Note

This study was presented at the 2013 American Association for Thoracic Surgery Mitral Conclave in New York in May 2013.


 

  • References

  • 1 Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children's Hospital. J Extra Corpor Technol 2012; 44 (3) 98-103
    PubMedGoogle Scholar
  • 2 Charette K, Gerrah R, Quaegebeur J , et al. Single dose myocardial protection technique utilizing del Nido cardioplegia solution during congenital heart surgery procedures. Perfusion 2012; 27 (2) 98-103
    CrossrefPubMedGoogle Scholar
  • 3 O'Blenes SB, Friesen CH, Ali A, Howlett S. Protecting the aged heart during cardiac surgery: the potential benefits of del Nido cardioplegia. J Thorac Cardiovasc Surg 2011; 141 (3) 762-770
    CrossrefPubMedGoogle Scholar
  • 4 Dobson GP, Jones MW. Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation. J Thorac Cardiovasc Surg 2004; 127 (3) 794-805
    CrossrefPubMedGoogle Scholar
  • 5 Ristagno G, Wang T, Tang W, Sun S, Castillo C, Weil MH. High-energy defibrillation impairs myocyte contractility and intracellular calcium dynamics. Crit Care Med 2008; 36 (11, Suppl): S422-S427
    CrossrefPubMedGoogle Scholar
  • 6 Steenbergen C, Murphy E, Watts JA, London RE. Correlation between cytosolic free calcium, contracture, ATP, and irreversible ischemic injury in perfused rat heart. Circ Res 1990; 66 (1) 135-146
    CrossrefPubMedGoogle Scholar