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Int J Sports Med 2015; 36(07): 535-541
DOI: 10.1055/s-0034-1398653
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Treadmill Running on Apelin and APJ Expression in Adipose Tissue and Skeletal Muscle in Rats Fed a High-fat Diet

H. Yang
1   School of P.E. and Sports Science, Beijing Normal University, School of P.E. and Sports Science, Beijing Normal University, Beijing, China
,
L. Zhao
2   Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, China
,
J. Zhang
2   Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, China
,
C.-S. Tang
2   Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, China
,
Y.-F. Qi
2   Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Peking University Health Science Center, Beijing, China
,
J. Zhang
1   School of P.E. and Sports Science, Beijing Normal University, School of P.E. and Sports Science, Beijing Normal University, Beijing, China
› Author Affiliations
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Publication History



accepted after revision 19 November 2014

Publication Date:
17 March 2015 (online)

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Abstract

Apelin, an adipokine and also a myokine, is involved in glucose homeostasis. In this study we investigated the effect of insulin resistance and exercise on the regulation of apelin and APJ in adipose tissue and skeletal muscle. After 20 weeks of a high-fat diet (HFD), rats showed severe insulin resistance, with increased fasting blood sugar and plasma insulin and impaired glucose tolerance. Plasma apelin immunoreactivity as well as apelin and APJ expression in adipose tissue and gastrocnemius muscle were significantly increased, with no difference in soleus muscle. Treadmill running completely ameliorated the HFD-induced insulin resistance, decreased plasma apelin level, and downregulated apelin and APJ expression in adipose tissue. However, apelin and APJ expression was upregulated in soleus and gastrocnemius muscle with treadmill training and a HFD. Exercise had a tissue-dependent effect on apelin and APJ expression in rats fed a HFD.

Key words

apelin - APJ - treadmill running - insulin resistance - skeletal muscle - adipose tissue
 

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