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DOI: 10.1055/s-0034-1394403
Relevanz von Bildgebungsbefunden für die Diagnostik und Therapie der adoleszenten Anorexia nervosa
Relevance of Neuroimaging Findings for Diagnoses and Treatment of Adolescent Anorexia nervosaPublication History
eingereicht 05 October 2014
akzeptiert 09 October 2014
Publication Date:
16 January 2015 (online)
![](https://www.thieme-connect.de/media/ppmp/201501/lookinside/thumbnails/10.1055-s-0034-1394403-1.jpg)
Zusammenfassung
Die Akutphase der Anorexia nervosa geht mit weitläufigen strukturellen Veränderungen der grauen und weißen Substanz des Gehirns einher. Aufgrund der Fortschritte im Bereich der Bildgebungsmethodik in den letzten Jahren konnten neue Erkenntnisse über die zerebralen Folgen und die Ätiologie von Essstörungen gewonnen werden. Dennoch ist die klinische Relevanz solcher Befunde bislang noch wenig diskutiert. Im vorliegenden Beitrag soll deshalb ein Überblick über potentielle Anwendungsfelder von neurowissenschaftlichen Forschungsergebnissen für die Diagnostik und Behandlung der Anorexia nervosa gegeben werden.
Abstract
Anorexia nervosa is associated with a marked loss of brain volumes during the acute stage of the disease. Due to the advances in neuroimaging methods during the last years our understanding of the consequences of starvation and the etiology of eating disorders has increased considerably, however, still the clinical relevance of these findings is limited. Thus, some future perspectives of neuroimaging findings for diagnoses and treatment of anorexia nervosa are summarized in the current review.
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Literatur
- 1 Seitz J, Bühren K, von Polier GG et al. Morphological changes in the brain of acutely ill and weight-recovered patients with anorexia nervosa. A meta-analysis and qualitative review. Z Kinder Jugendpsychiatr Psychother 2014; 42: 7-17
- 2 Titova 1 OE, Hjorth OC, Schiöth HB et al. Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies. BMC Psychiatry 2013; 13: 110
- 3 Brooks SJ, Barker GJ, O’Daly OG et al. Restraint of Appetite and Reduced Regional Brain Volumes in Anorexia nervosa: a Voxel-based Morphometric Study. BMC Psychiatry 2011; 11: 179
- 4 Chui HT, Christensen BK, Zipursky RB et al. Cognitive Function and Brain Structure in Females with a History of Adolescent-onset Anorexia nervosa. Pediatrics 2008; 122: e426-e437
- 5 Mainz V, Schulte-Rüther M, Fink GR et al. Structural Brain Alterations In Anorexia nervosa Patients Before And After Weight Recovery. J Am Acad Child Adolesc Psychiatry 2012; 51: 832-841
- 6 Friederich HC, Walther S, Bendszus M. Grey Matter Abnormalities Within Cortico-limbic-striatal Circuits in Acute and Weight-restored Anorexia nervosa Patients. Neuroimage 2012; 59: 1106-1113
- 7 McCormick LM, Keel PK, Brumm MC. Implications of Starvation-induced Change in Right Dorsal Anterior Cingulate Volume in Anorexia nervosa. International Journal of Eating Disorders 2008; 41: 602-610
- 8 Muhlau MC, Gaser R, Ilg B et al. Gray Matter Decrease of the Anterior Cingulate Cortex in Anorexia nervosa. Am J Psychiatry 2007; 164: 1850-1857
- 9 Boghi AS, Sterpone S, Sales S et al. In Vivo Evidence of Global and Focal Brain Alterations in Anorexia nervosa. Psychiatry Research 2011; 192: 154-159
- 10 Neumarker KJ, Bzufka WM, Dudeck U et al. Are There Specific Disabilities of Number Processing in Adolescent Patients with Anorexia nervosa? Evidence from Clinical and Neuropsychological Data When Compared to Morphometric Measures from Magnetic Resonance Imaging. European Child and Adolescent Psychiatry 2000; (Suppl 2) II111-II121
- 11 Garcia-Ruiz MS, Diaz-Cintra S, Cintra L et al. Effect of Protein Malnutrition on CA3 Hippocampal Pyramidal Cells in Rats of Three Ages. Brain Research 1993; 625: 203-212
- 12 Wagner A, Aizenstein H, Venkatraman VK et al. Reward processing in women recovered from anorexia nervosa. Am J Psychiatry 2007; 164: 1842-1849
- 13 Zastrow A, Kaiser S, Stippich C et al. Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa. Am J Psychiatry 2009; 166: 608-616
- 14 Schulte-Rüther M, Mainz V, Fink GR et al. Theory of mind and the brain in anorexia nervosa: relation to treatment outcome. J Am Acad Child Adolesc Psychiatry 2012; 51: 832-841
- 15 Sholl SA, Kim KL. Estrogen receptors in the rhesus monkey brain during fetal development. Brain Res Dev Brain Res 1989; 50: 189-196
- 16 Neufang S, Specht K, Hausmann M et al. Sex differences and the impact of steroid hormones on the developing human brain. Cerebral Cortex 2009; 19: 464-473
- 17 Wise PM. Estrogen therapy: does it help or hurt the adult and aging brain? Insights derived from animal models. Neuroscience 2006; 138: 831-835
- 18 Peper JS, van den Heuvel MP, Mandl RC et al. Sex steroids and connectivity in the human brain: a review of neuroimaging studies. Psychoneuroendocrinology 2011; 36: 1101-1113
- 19 Buehren K, Konrad K, Schaefer K et al. Association Between Neuroendocrinological Parameters and Learning and Memory Functions in Adolescent Anorexia nervosa before and after Weight Recovery. Journal of Neural Transmission 2011; 118: 963-968
- 20 Wentz E, Gillberg IC, Anckarsater H et al. Adolescent-onset anorexia nervosa: 18-year outcome. The British Journal of Psychiatry 2009; 194: 168-174
- 21 Frank GK, Shott ME, Hagman JO et al. Localized brain volume and white matter integrity alterations in adolescent anorexia nervosa. Journal of the American Academy of Child and Adolescent Psychiatry 2013; 52: 1066-1075
- 22 Talbot A, Hay P, Buckett G et al. Cognitive deficits as an endophenotype for anorexia nervosa: An accepted fact or a need for re-examination?. Int J Eat Disord 2014; DOI: 10.1002/eat.22332. [Epub ahead of print]
- 23 Tchanturia K, Davies H, Campbell IC. Cognitive remediation therapy for patients with anorexia nervosa: preliminary findings. Ann Gen Psychiatry 2007; 6: 14
- 24 Brockmeyer 1 T, Ingenerf K, Walther S et al. Training cognitive flexibility in patients with anorexia nervosa: a pilot randomized controlled trial of cognitive remediation therapy. Int J Eat Disord 2014; 47: 24-31
- 25 McClelland J, Bozhilova N, Campbell I et al. A systematic review of the effects of neuromodulation on eating and body weight: evidence from human and animal studies. Eur Eat Disord Rev 2013; 21: 436-455
- 26 Oudijn MS, Storosum JG, Nelis E et al. Is deep brain stimulation a treatment option for anorexia nervosa?. BMC Psychiatry 2013; 13: 277