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Zeitschrift für Orthomolekulare Medizin 2014; 12(4): 11-13
DOI: 10.1055/s-0034-1383295
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Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart · New York

Vitamin D und seine Bedeutung für die geistige Gesundheit

Michael F. Holick
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Publication History

Publication Date:
18 December 2014 (online)

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Zusammenfassung

Die ausreichende Vitamin-D-Versorgung ist von der Gravidität bis ins Alter wichtig für die Entwicklung und Gesunderhaltung des Gehirns. Ein Mangel führt über verschiedene Mechanismen zum Abbau neurokognitiver Fähigkeiten und erhöht das Risiko für neurologische Störungen wie Demenz und Alzheimer-Krankheit.

Schlüsselwörter

Vitamin D - geistige Gesundheit - Demenz - Alzheimer-Krankheit - Gehirnentwicklung - Vitamin-D-Mangel - Supplementierung

Literaturverzeichnis als PDF

 

  • Literatur

  • 1 Littlejohns TJ, Henley WE, Lang LA et al. Vitamin D and risk of dementia and Alzheimerʼs disease. Neurology 2014; 83 (10) 920-928
    CrossrefGoogle Scholar
  • 2 Sutherland MK, Somerville MJ, Yoong LK. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28 k mRNA levels. Brain Res Mol Brain Res 1992; 13 (3) 239-250
    CrossrefGoogle Scholar
  • 3 Eyles DW, Smith S, Kinobe R. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005; 29 (1) 21-30
    CrossrefGoogle Scholar
  • 4 Dhikav V, Anand K. Potential predictors of hippocampal atrophy in Alzheimerʼs disease. Drugs Aging 2011; 28 (1) 1-11
    CrossrefGoogle Scholar
  • 5 Mu Y, Gage FH. Adult hippocampal neurogenesis and its role in Alzheimerʼs disease. Mol Neurodegener 2011; 6: 85
    CrossrefGoogle Scholar
  • 6 Fotuhi M, Do D, Jack C. Modifiable factors that alter the size of the hippocampus with ageing. Nat Rev Neurol 2012; 8 (4) 189-202
    Google Scholar
  • 7 Calabresi P, Castrioto A, Di Filippo M, Picconi B. New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinsonʼs disease. Lancet Neurol 2013; 12 (8) 811-821
    CrossrefGoogle Scholar
  • 8 Nimitphong H, Holick MF. Vitamin D, neurocognitive functioning and immunocompetence. Curr Opin Clin Nutr Metab Care 2011; 14 (1) 7-14
    CrossrefGoogle Scholar
  • 9 Beydoun MA, Ding EL, Beydoun HA. Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults. Am J Clin Nutr 2012; 95 (1) 163-178
    CrossrefGoogle Scholar
  • 10 Kuningas M, Mooijaart SP, Jolles J. VDR gene variants associate with cognitive function and depressive symptoms in old age. Neurobiol Aging 2009; 30 (3) 466-473
    CrossrefGoogle Scholar
  • 11 Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI. Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimerʼs disease. Am J Med Genet B Neuropsychiatr Genet 2003; 117B(1): 114-117
    CrossrefGoogle Scholar
  • 12 Gezen-Ak D, Dursun E, Ertan T et al. Association between vitamin D receptor gene polymorphism and Alzheimerʼs disease. Tohoku J Exp Med 2007; 212 (3) 275-282
    CrossrefGoogle Scholar
  • 13 Lehmann DJ, Refsum H, Warden DR et al. The vitamin D receptor gene is associated with Alzheimerʼs disease. Neurosci Lett 2011; 504 (2) 79-82
    CrossrefGoogle Scholar
  • 14 Gezen-Ak D, Dursun E, Bilgiç B et al. Vitamin D receptor gene haplotype is associated with late-onset Alzheimerʼs disease. Tohoku J Exp Med 2012; 228 (3) 189-196
    CrossrefGoogle Scholar
  • 15 Kim JS, Kim YI, Song C et al. Association of vitamin D receptor gene polymorphism and Parkinsonʼs disease in Koreans. J Korean Med Sci 2005; 20 (3) 495-498
    CrossrefGoogle Scholar
  • 16 Butler MW, Burt A, Edwards TL et al. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet 2011; 75 (2) 201-210
    CrossrefGoogle Scholar
  • 17 Krizova L, Kollar B, Jezova D, Turcani P. Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. Gen Physiol Biophys 2013; 32 (4) 459-466
    CrossrefGoogle Scholar
  • 18 Groves NJ, McGrath JJ, Burne THJ. Vitamin D as a neurosteroid affecting the developing and adult brain. Annu Rev Nutr 2014; 34: 117-141
    CrossrefPubMedGoogle Scholar
  • 19 Ko P, Burkert R, McGrath J, Eyles D. Maternal vitamin D deprivation and the regulation of apoptosis and cell cycle during rat brain development. Brain Res Dev Brain Res 2004; 153: 61-68
    CrossrefGoogle Scholar
  • 20 Schlogl M, Holick MF. Vitamin D and neurocognitive function. Clinical Interventions in Aging 2014; 9: 559-568
    Google Scholar
  • 21 Dursun E, Gezen-Ak D, Yilmazer S. A new mechanism for amyloid-β-induction of iNOS: vitamin D-VDR pathway disruption. J Alzheimerʼs Dis 2013; 36: 459-474
    Google Scholar
  • 22 Balden R, Selvamani A, Sohrabji F. Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology 2012; 153: 2420-2435
    CrossrefGoogle Scholar
  • 23 Lefebvre dʼHellencourt C, Montero-Menei CN, Bernard R, Couez D. Vitamin D3 inhibits Proinflammatory cytokines and nitric oxide production by the EOC13 microglial cell line. J Neurosci Res 2013; 71: 575-582
    Google Scholar
  • 24 Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281
    CrossrefPubMedGoogle Scholar
  • 25 Gezen-Ak D, Dursun E, Yilmazer S. The effects of vitamin D receptor silencing on the expression of LVSCC-A1C and LVSCC-A1D and the release of NGF in cortical neurons. PLoS ONE 2011; 6: e17553
    CrossrefGoogle Scholar
  • 26 Annweiler C et al. Vitamin D supplements: a novel therapeutic approach for alzheimer patients. Front Pharmacol 2014; 5: 6
    Google Scholar
  • 27 Balion C, Griffith LE, Strifler L et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology 2012; 79 (13) 1397-1405
    CrossrefGoogle Scholar
  • 28 Buell JS, Dawson-Hughes B, Scott TM et al. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 2010; 74 (1) 18-26
    CrossrefGoogle Scholar
  • 29 Annweiler C, Fantino B, Le Gall D et al. Severe vitamin D deficiency is associated with advanced-stage dementia in geriatric inpatients. J Am Geriatr Soc 2011; 59 (1) 169-171
    CrossrefGoogle Scholar
  • 30 Annweiler C, Rolland Y, Schott AM et al. Higher vitamin D dietary intake is associated with lower risk of alzheimerʼs disease: a 7-year follow-up. J Gerontol A Biol Sci Med Sci 2012; 67 (11) 1205-1211
    CrossrefGoogle Scholar
  • 31 Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimerʼs disease: a systematic review and meta-analysis. J Alzheimers Dis 2013; 33 (3) 659-674
    Google Scholar
  • 32 Barnard K, Colón-Emeric C. Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition. Am J Geriatr Pharmacother 2010; 8 (1) 4-33
    CrossrefGoogle Scholar
  • 33 Annweiler C, Montero-Odasso M, Llewellyn DJ et al. Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimers Dis 2013; 37 (1) 147-171
    Google Scholar
  • 34 van der Schaft J, Koek HL, Dijkstra E et al. The association between vitamin D and cognition: a systematic review. Ageing Res Rev 2013; 12 (4) 1013-1023
    CrossrefGoogle Scholar
  • 35 Llewellyn DJ, Lang IA, Langa KM et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med 2010; 170 (13) 1135-1141
    CrossrefPubMedGoogle Scholar
  • 36 Slinin Y, Paudel ML, Taylor BC et al. Osteoporotic Fractures in Men (MrOS) Study Research Group. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology 2010; 74 (1) 33-41
    CrossrefGoogle Scholar
  • 37 Slinin Y, Paudel M, Taylor BC et al. Study of Osteoporotic Fractures Research Group. Association between serum 25(OH) vitamin D and the risk of cognitive decline in older women. J Gerontol A Biol Sci Med Sci 2012; 67 (10) 1092-1098
    CrossrefGoogle Scholar
  • 38 Gröber U, Holick MF. Vitamin D: Die Heilkraft des Sonnenvitamins. 3., aktualisierte Aufl. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2015
    Google Scholar
  • 39 Ross AC, Manson JE, Abrams SA et al. The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know. J Clin Endocrinol Metab 2011; 96 (1) 53-58
    CrossrefPubMedGoogle Scholar
  • 40 Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96 (7) 1911-1930
    CrossrefPubMedGoogle Scholar
  • 41 Gröber U, Spitz J, Reichrath J et al. Vitamin D. Update 2013. From rickets prophylaxis to general healthcare. Dermatoendocrinol 2013; 5 (3) 331-347
    CrossrefGoogle Scholar