Synlett 2015; 26(05): 572-579
DOI: 10.1055/s-0034-1379964
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© Georg Thieme Verlag Stuttgart · New York

Strategies for the Synthesis of Antifeedant Leucosceptroid Natural Products

Cedric L. Hugelshofer
Department of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich, Butenandstr. 5–13, 81377 Munich, Germany   Email: thomas.magauer@lmu.de
,
Thomas Magauer*
Department of Chemistry and Pharmacy, Ludwig-Maximilians-University Munich, Butenandstr. 5–13, 81377 Munich, Germany   Email: thomas.magauer@lmu.de
› Author Affiliations
Further Information

Publication History

Received: 30 October 2014

Accepted after revision: 09 December 2014

Publication Date:
12 January 2015 (online)


Abstract

The evolving pathogen resistance in agricultural pests requires the development of novel chemical agents to maintain efficient pest control. Biological screening of natural products isolated from Leucosceptrum canum Smith led to the discovery of active antifeedant sesterterpenoids. This article highlights recent progress towards the synthesis of these natural products.

1 Introduction

2 Synthesis of the Leucosceptroid Core Structure

3 Total Synthesis of Leucosceptroid B

4 Towards the Collective Synthesis of Leucosceptroid Natural Products

5 Total Synthesis of Leucosceptroids A and B

6 Summary

 
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