Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2015; 11(1): 0050
DOI: 10.1055/s-0034-1379759
DOI: 10.1055/s-0034-1379759
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Rhodium-Catalyzed Enantioselective Hydrogenation of Enamido Esters
Further Information
Publication History
Publication Date:
15 December 2014 (online)
Significance
Lv, Zhang and colleagues present a rhodium-catalyzed asymmetric hydrogenation of α-acetoxy β-enamido esters. A series of chiral α-hydroxy-β-amino acid derivatives were prepared in high yields (up to 98%) with excellent enantioselectivities (up to 97% ee).
#
Comment
[Rh(nbd)(Sc,Rp)-DuanPhos]BF4 is found to be an effective catalyst for the enantioselective hydrogenation of tetrasubstituted enamides. The synthetic utility of this method is demonstrated by the synthesis of biologically important molecules.
#
#