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Synfacts 2015; 11(1): 0053
DOI: 10.1055/s-0034-1379749
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Reduction of α-Amino Ketones Catalyzed by Lewis Acids

Contributor(s):
Hisashi Yamamoto
,
Yasushi Shimoda
He P, Zheng H, Liu X, Lian X, Lin L, Feng X * Sichuan University, Chengdu, P. R. of China
Asymmetric Reduction of α-Amino Ketones with KBH4 Solution Catalyzed by Chiral Lewis Acids.

Chem. Eur. J. 2014;
20: 13482-13486
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Further Information

Publication History

Publication Date:
15 December 2014 (online)

 
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Key words

amino ketones - reduction - nickel - scandium

Significance

The authors developed a metal-catalyzed asymmetric reduction of α-amino ketones using KBH4 as hydride source. Under mild conditions, desired amino alcohols are obtained with high enantioselectivities.


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Comment

β-Amino alcohols are important structural motif in natural or pharmaceutical compounds. The authors also presented a gram-scale version of this reaction and its possible transition state.


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