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Synfacts 2015; 11(1): 0110
DOI: 10.1055/s-0034-1379714
DOI: 10.1055/s-0034-1379714
Polymer-Supported Synthesis
N-Formylation of Amines Using Molybdate Sulfuric Acid
Further Information
Publication History
Publication Date:
15 December 2014 (online)
Significance
Molybdate sulfuric acid (MSA) catalyzed the N-formylation of amines with orthoformates to give the corresponding formamide derivatives in up to 95% yield (19 examples). In the N-formylation of aniline with triethyl orthoformate, the catalyst was recovered by filtration and reused three times with a slight loss of catalytic activity (1st reuse: 87% yield, 3rd reuse: 80% yield).
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Comment
The catalytic activity of MSA was superior to that of the other catalysts (ZnO, ZrOCl2, MgBr2, ZnCl2, and H2SO4).The authors have reported previously the preparation of molybdate sulfuric acid and its application to the synthesis of phenazines and quinoxalines (Polycycl. Aromat. Compd. 2011, 31, 97).
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