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Synfacts 2015; 11(1): 0076
DOI: 10.1055/s-0034-1379653
DOI: 10.1055/s-0034-1379653
Metal-Mediated Synthesis
Nickel-Catalyzed Intramolecular Cyclization of Dihaloalkanes
Further Information
Publication History
Publication Date:
15 December 2014 (online)
Significance
The authors have developed an intramolecular cyclization of nitrogen- and carbon-tethered dihaloalkanes. The protocol is especially effective for five-membered rings and only moderately for six-membered rings. The reactions were performed under mild reactions conditions.
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Comment
The coupling involving secondary alkyl halides appears to be more efficient than the cyclization of primary/primary alkyl dihalides. Interestingly, the construction of a seven-membered ring is less efficient. Side-reactions are intermolecular oligomerization and hydrodehalogenation of the substrate.
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