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Synthesis 2014; 46(21): 2927-2936
DOI: 10.1055/s-0034-1379003
DOI: 10.1055/s-0034-1379003
paper
Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle
Further Information
Publication History
Received: 17 June 2014
Accepted after revision: 28 July 2014
Publication Date:
15 August 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201421/lookinside/thumbnails/10.1055-s-0034-1379003-1.jpg)
Abstract
The synthesis of a new ‘eastern domain’ of a proposed dihydroarchazolid analogue is described along with initial results from attempted macrocyclization by ring-closing metathesis. This work has revealed a competing backbiting process that may be preventable by alcohol functionalization and installation of a metathesis relay.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084. Included are spectral data for compounds 9, 10, 12, 13, 17, 18–26.
- Supporting Information
-
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