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Synthesis 2015; 47(16): 2439-2445
DOI: 10.1055/s-0034-1378715
DOI: 10.1055/s-0034-1378715
special topic
Three-Component Photoredox-Mediated Chloro-, Bromo-, or Iodotrifluoromethylation of Alkenes
Further Information
Publication History
Received: 26 March 2015
Accepted after revision: 01 May 2015
Publication Date:
19 June 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201516/lookinside/thumbnails/ss-2015-c0200-st_10-1055_s-0034-1378715-1.jpg)
Abstract
A mild and simple three-component procedure for the direct vicinal halotrifluoromethylation of styrenes and aliphatic alkenes has been developed in the presence of [Ru(bpy)3](PF6)2 as a photosensitizer and Umemoto’s reagent as the CF3 source. The multicomponent method offers the advantage of short reaction time, moderate to good yields, and mild reaction conditions.
Key words
multicomponent reaction - halotrifluoromethylation - photoredox catalysis - halogen - Umemoto’s reagentSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378715.
- Supporting Information
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For recent reviews, see:
For recent reviews on photoredox catalysis, see:
The other methods of halotrifluoromethylation are mostly related to radical group tranfer and are summarized in the following selected reviews:
For recent examples of MCRs using photoredox catalysis, see: