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Synthesis 2014; 46(13): 1802-1806
DOI: 10.1055/s-0033-1341227
DOI: 10.1055/s-0033-1341227
paper
Nitrile Synthesis through Catalyzed Cascades Involving Acid–Nitrile Exchange
Further Information
Publication History
Received: 25 February 2014
Accepted: 21 March 2014
Publication Date:
30 April 2014 (online)
Abstract
Irreversible acid–nitrile exchange reactions using both glutaronitrile and (phenylsulfonyl)acetonitrile may be catalyzed by Lewis acids. Whereas a cyclization towards imides displaces the equilibria in the reaction with dinitriles, a decarboxylation step is involved when using the (phenylsulfonyl)acetonitrile.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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Cyanoacetic acid derivatives are known to spontaneously decarboxylate under 200 °C: