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Synfacts 2014; 10(1): 0071
DOI: 10.1055/s-0033-1340366
DOI: 10.1055/s-0033-1340366
Metal-Mediated Synthesis
Co/Ti Cooperative C(sp2)–C(sp2) Cross-Coupling Reactions
Further Information
Publication History
Publication Date:
13 December 2013 (online)
![](https://www.thieme-connect.de/media/synfacts/201401/i_p156_s1_10-1055_s-0033-1340366.gif)
Significance
A novel method for cobalt-catalyzed cross-coupling reactions between aryl chlorides or bromides and aromatic magnesium or lithium reagents is reported by Duan and co-workers. The presence of 40 mol% of Ti(OEt)4 suppresses undesired homocoupling side-products resulting from the organometallic reagent.
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Comment
Interestingly, the reaction can also take place in the presence of a free carboxylic acid, a hydroxyl, or an amide residue. Therefore, this protocol allows an efficient arylation of highly functionalized aryl halides without protection–deprotection sequences.
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![](https://www.thieme-connect.de/media/synfacts/201401/i_p156_s1_10-1055_s-0033-1340366.gif)