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Synthesis 2013; 45(24): 3392-3398
DOI: 10.1055/s-0033-1339917
DOI: 10.1055/s-0033-1339917
paper
A New [2+2+1] Heterocyclization for the Synthesis of 2,3,5-Trisubstituted Thiophenes under Microwave Irradiation
Further Information
Publication History
Received: 10 August 2013
Accepted after revision: 16 September 2013
Publication Date:
08 October 2013 (online)
Abstract
A new three-component strategy for the efficient synthesis of 2,3,5-trisubstituted thiophene derivatives through a [2+2+1] heterocyclization between 3-(2-aryl-2-oxoethylidene)-2-oxindoles and α-thiocyanato ketones under microwave irradiation is described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble thiophene scaffolds.
Key words
heterocyclization - substituted thiophene - three-component reactions - α-thiocyanato ketone - 3-(2-aryl-2-oxoethylidene)-2-oxindoleSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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