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Semin Reprod Med 2013; 31(02): 173-177
DOI: 10.1055/s-0032-1333483
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Oocyte Donation and Endometriosis: What Are the Lessons?

Erik E. Hauzman
1   Division of Reproductive Endocrinology and Infertility IVI-Madrid
,
Juan A. Garcia-Velasco
1   Division of Reproductive Endocrinology and Infertility IVI-Madrid
2   Department of Obstetrics and Gynecology, Rey Juan Carlos University, Madrid, Spain
,
Antonio Pellicer
3   Division of Reproductive Endocrinology and Infertility IVI-Valencia
4   Department of Pediatrics, Obstetrics and Gynecology, Valencia University, Valencia, Spain
› Author Affiliations
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Publication History

Publication Date:
27 February 2013 (online)

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Abstract

Outcomes of in vitro fertilization cycles in women with endometriosis are significantly worse than in patients without this condition. The impact of endometriosis on ovarian reserve and the quality of retrieved oocytes seems evident. Lower implantation rates, however, raise the question whether this finding is purely the consequence of lower number and poorer quality of embryos, or whether it also reflects compromised endometrial receptivity. Oocyte donation provides an interesting model to investigate reproductive outcome because factors affecting the oocytes are excluded, especially if cycles using oocytes derived from the same donor are analyzed. These studies have shown lower implantation rates in nonendometriotic patients who received oocytes from women with endometriosis, whereas healthy donated oocytes have proven to contribute to a pregnancy with similar chances in women without the disease. The question still to be answered is whether this situation applies for natural cycles or whether it is the use of gonadotropin-releasing hormone analogs and hormonal replacement therapy used for endometrial priming in oocyte recipients that reestablishes an adequate uterine environment. Using a genomic tool based on microarray technology (endometrial receptivity array), the study of differential gene expression in the eutopic endometrium of endometriosis patients undergoing oocyte donation treatment is still underway.

Keywords

endometriosis - oocyte donation - endometrial receptivity
 

  • References

  • 1 Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am 1997; 24 (2) 235-258
    CrossrefPubMedGoogle Scholar
  • 2 Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril 2009; 92 (1) 68-74
    CrossrefPubMedGoogle Scholar
  • 3 Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril 2008; 90 (2) 247-257
    CrossrefPubMedGoogle Scholar
  • 4 Zinaman MJ, Clegg ED, Brown CC, O'Connor J, Selevan SG. Estimates of human fertility and pregnancy loss. Fertil Steril 1996; 65 (3) 503-509
    PubMedGoogle Scholar
  • 5 Guzick DS, Silliman NP, Adamson GD , et al. Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis. Fertil Steril 1997; 67 (5) 822-829
    CrossrefPubMedGoogle Scholar
  • 6 Simón C, Gutiérrez A, Vidal A , et al. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod 1994; 9 (4) 725-729
    CrossrefPubMedGoogle Scholar
  • 7 Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril 2002; 77 (6) 1148-1155
    CrossrefPubMedGoogle Scholar
  • 8 Kuivasaari P, Hippeläinen M, Anttila M, Heinonen S. Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod 2005; 20 (11) 3130-3135
    CrossrefPubMedGoogle Scholar
  • 9 Kennedy S, Bergqvist A, Chapron C , et al; ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 2005; 20 (10) 2698-2704
    CrossrefPubMedGoogle Scholar
  • 10 Opøien HK, Fedorcsák P, Omland AK , et al. In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril 2012; 97 (4) 912-918
    CrossrefPubMedGoogle Scholar
  • 11 Arici A, Oral E, Bukulmez O, Duleba A, Olive DL, Jones EE. The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program. Fertil Steril 1996; 65 (3) 603-607
    PubMedGoogle Scholar
  • 12 Yanushpolsky EH, Best CL, Jackson KV, Clarke RN, Barbieri RL, Hornstein MD. Effects of endometriomas on oocyte quality, embryo quality, and pregnancy rates in in vitro fertilization cycles: a prospective, case-controlled study. J Assist Reprod Genet 1998; 15 (4) 193-197
    CrossrefPubMedGoogle Scholar
  • 13 Brizek CL, Schlaff S, Pellegrini VA, Frank JB, Worrilow KC. Increased incidence of aberrant morphological phenotypes in human embryogenesis—an association with endometriosis. J Assist Reprod Genet 1995; 12 (2) 106-112
    CrossrefPubMedGoogle Scholar
  • 14 Pellicer A, Oliveira N, Ruíz A, Remohí J, Simón C. Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction. Hum Reprod 1995; 10 (Suppl. 02) 91-97
    CrossrefPubMedGoogle Scholar
  • 15 Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97 (5) 1028-1032
    CrossrefPubMedGoogle Scholar
  • 16 Paulson RJ. Hormonal induction of endometrial receptivity. Fertil Steril 2011; 96 (3) 530-535
    CrossrefPubMedGoogle Scholar
  • 17 Kao LC, Tulac S, Lobo S , et al. Global gene profiling in human endometrium during the window of implantation. Endocrinology 2002; 143 (6) 2119-2138
    CrossrefPubMedGoogle Scholar
  • 18 Altmäe S, Martínez-Conejero JA, Salumets A, Simón C, Horcajadas JA, Stavreus-Evers A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3) 178-187
    CrossrefPubMedGoogle Scholar
  • 19 Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA , et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011; 95 (1) 50-60, e1–e15
    CrossrefPubMedGoogle Scholar
  • 20 Garrido N, Navarro J, García-Velasco JA, Remoh J, Pellice A, Simón C. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update 2002; 8 (1) 95-103
    CrossrefPubMedGoogle Scholar
  • 21 Lessey BA, Castelbaum AJ, Buck CA, Lei Y, Yowell CW, Sun J. Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril 1994; 62 (3) 497-506
    PubMedGoogle Scholar
  • 22 Sharpe-Timms KL, Keisler LW, McIntush EW, Keisler DH. Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis and restored in sera by gonadotropin-releasing hormone agonist therapy. Fertil Steril 1998; 69 (6) 1128-1134
    CrossrefPubMedGoogle Scholar
  • 23 Taketani Y, Kuo TM, Mizuno M. Comparison of cytokine levels and embryo toxicity in peritoneal fluid in infertile women with untreated or treated endometriosis. Am J Obstet Gynecol 1992; 167 (1) 265-270
    CrossrefPubMedGoogle Scholar
  • 24 Ulukus M, Arici A. Immunology of endometriosis. Minerva Ginecol 2005; 57 (3) 237-248
    PubMedGoogle Scholar
  • 25 Kao LC, Germeyer A, Tulac S , et al. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 2003; 144 (7) 2870-2881
    CrossrefPubMedGoogle Scholar
  • 26 Margarit L, Gonzalez D, Lewis PD , et al. L-selectin ligands in human endometrium: comparison of fertile and infertile subjects. Hum Reprod 2009; 24 (11) 2767-2777
    CrossrefPubMedGoogle Scholar
  • 27 Margarit L, Taylor A, Roberts MH , et al. MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis. J Clin Endocrinol Metab 2010; 95 (12) 5320-5329
    CrossrefPubMedGoogle Scholar
  • 28 Sundqvist J, Andersson KL, Scarselli G, Gemzell-Danielsson K, Lalitkumar PG. Expression of adhesion, attachment and invasion markers in eutopic and ectopic endometrium: a link to the aetiology of endometriosis. Hum Reprod 2012; 27 (9) 2737-2746
    CrossrefPubMedGoogle Scholar
  • 29 Matsuzaki S, Darcha C, Maleysson E, Canis M, Mage G. Impaired down-regulation of E-cadherin and beta-catenin protein expression in endometrial epithelial cells in the mid-secretory endometrium of infertile patients with endometriosis. J Clin Endocrinol Metab 2010; 95 (7) 3437-3445
    CrossrefPubMedGoogle Scholar
  • 30 Lessey BA, Castelbaum AJ, Sawin SW , et al. Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab 1994; 79 (2) 643-649
    CrossrefPubMedGoogle Scholar
  • 31 Wei Q, St Clair JB, Fu T, Stratton P, Nieman LK. Reduced expression of biomarkers associated with the implantation window in women with endometriosis. Fertil Steril 2009; 91 (5) 1686-1691
    CrossrefPubMedGoogle Scholar
  • 32 Donaghay M, Lessey BA. Uterine receptivity: alterations associated with benign gynecological disease. Semin Reprod Med 2007; 25 (6) 461-475
    Article in Thieme ConnectPubMedGoogle Scholar
  • 33 Nadir Ciray H, Bener F, Karagenç L, Ulug U, Bahçeci M. Impact of assisted hatching on ART outcome in women with endometriosis. Hum Reprod 2005; 20 (9) 2546-2549
    CrossrefPubMedGoogle Scholar
  • 34 Cunha-Filho JS, Gross JL, Bastos de Souza CA , et al. Physiopathological aspects of corpus luteum defect in infertile patients with mild/minimal endometriosis. J Assist Reprod Genet 2003; 20 (3) 117-121
    CrossrefPubMedGoogle Scholar
  • 35 Ayers JW, Birenbaum DL, Menon KM. Luteal phase dysfunction in endometriosis: elevated progesterone levels in peripheral and ovarian veins during the follicular phase. Fertil Steril 1987; 47 (6) 925-929
    PubMedGoogle Scholar
  • 36 Lessey BA, Killam AP, Metzger DA, Haney AF, Greene GL, McCarty Jr KS. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 1988; 67 (2) 334-340
    CrossrefPubMedGoogle Scholar
  • 37 Wu Y, Strawn E, Basir Z, Halverson G, Guo SW. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis. Epigenetics 2006; 1 (2) 106-111
    CrossrefPubMedGoogle Scholar
  • 38 Díaz I, Navarro J, Blasco L, Simón C, Pellicer A, Remohí J. Impact of stage III-IV endometriosis on recipients of sibling oocytes: matched case-control study. Fertil Steril 2000; 74 (1) 31-34
    CrossrefPubMedGoogle Scholar
  • 39 Garcia-Velasco JA, Isaza V, Caligara C, Pellicer A, Remohí J, Simón C. Factors that determine discordant outcome from shared oocytes. Fertil Steril 2003; 80 (1) 54-60
    PubMedGoogle Scholar
  • 40 Bodri D, Colodrón M, Vidal R, Galindo A, Durban M, Coll O. Prognostic factors in oocyte donation: an analysis through egg-sharing recipient pairs showing a discordant outcome. Fertil Steril 2007; 88 (6) 1548-1553
    CrossrefPubMedGoogle Scholar
  • 41 Pellicer A, Oliveira N, Gutierrez A , et al. Implantation in endometriosis: Lessons learned from IVF and oocyte donation. In: Spinola P, Coutinho EM, , eds. Progress in Endometriosis. Casterton-Hill, United Kingdom: Parthenon Publishing Group; 1994: 177-183
    Google Scholar
  • 42 Budak E, Garrido N, Soares SR , et al. Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies. Fertil Steril 2007; 88 (2) 342-349
    CrossrefPubMedGoogle Scholar
  • 43 Imai A, Takagi A, Tamaya T. Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro. Am J Obstet Gynecol 2000; 182 (5) 1142-1146
    CrossrefPubMedGoogle Scholar
  • 44 Surrey ES, Silverberg KM, Surrey MW, Schoolcraft WB. Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis. Fertil Steril 2002; 78 (4) 699-704
    CrossrefPubMedGoogle Scholar
  • 45 Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev 2006; 25 (1) CD004635
    PubMedGoogle Scholar
  • 46 Garcia-Velasco JA, Nikas G, Remohí J, Pellicer A, Simón C. Endometrial receptivity in terms of pinopode expression is not impaired in women with endometriosis in artificially prepared cycles. Fertil Steril 2001; 75 (6) 1231-1233
    CrossrefPubMedGoogle Scholar