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Synlett 2013; 24(8): 1016-1020
DOI: 10.1055/s-0032-1316898
DOI: 10.1055/s-0032-1316898
letter
Synthesis of Phenanthridin-6(5H)-ones via Copper-Catalyzed Cyclization of 2-Phenylbenzamides
Further Information
Publication History
Received: 25 January 2013
Accepted after revision: 12 March 2013
Publication Date:
28 March 2013 (online)
Abstract
Synthesis of phenanthridin-6(5H)-ones was achieved via copper-catalyzed cyclization of 2-phenylbenzamides using air as the oxidant and KOt-Bu as the base. It was discovered that, besides Ph3P, other ligands such as 1,10-phenanthroline, TMEDA as well as l-proline could also be used as the ligand to effect the transformation.
Supporting Information
- Experimental procedures, characterization data, and copies of 1H NMR and 13C NMR spectra for this article are available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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References and Notes
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For some examples of nickel-catalyzed C–C and C–X bond-forming reactions, see:
For some examples of copper-catalyzed C–C and C–X bond-forming reactions, see:
For some examples of iron-catalyzed C–C and C–X bond-forming reactions, see: