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Synthesis 2013; 45(4): 518-526
DOI: 10.1055/s-0032-1316841
DOI: 10.1055/s-0032-1316841
paper
Dilithium Tetrachlorocuprate(II) Catalyzed Oxidative Homocoupling of Functionalized Grignard Reagents
Weitere Informationen
Publikationsverlauf
Received: 24. September 2012
Accepted after revision: 16. Dezember 2012
Publikationsdatum:
10. Januar 2013 (online)


Abstract
An efficient procedure is described for the oxidative homocoupling of functionalized Grignard reagents using a catalytic amount of dilithium tetrachlorocuprate(II) (CuLi2Cl4) in the presence of pure oxygen gas. This method is applied successfully to a variety of aryl, heteroaryl, alkyl, alkenyl and alkynyl halides, which are converted into the corresponding homocoupled products in good to excellent yields.
Key words
homocoupling - dilithium tetrachlorocuprate(II) - Grignard reagents - oxidant - metalationSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information