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Intensivmedizin up2date 2012; 08(03): 145-157
DOI: 10.1055/s-0032-1309907
Allgemeine Prinzipien der Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Akutes Leberversagen

Tina Brunnenberg
,
Vito R. Cicinnati
,
Hartmut H.-J. Schmidt
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Publication Date:
13 August 2012 (online)

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Kernaussagen

  • Das akute Leberversagen (ALV) ist ein seltenes und lebensbedrohliches Krankheitsbild mit einem plötzlichen Verlust der Leberfunktion ohne eine vorbestehende Lebererkrankung.

  • Die medikamentös-toxisch induzierte Leberschädigung (v. a. Paracetamol) und hepatotrope Viren sind in den westlichen Industrieländern am häufigsten verantwortlich für ein ALV. Beim ALV unklarer Genese sollte man differenzialdiagnostisch eine Autoimmunhepatitis in Betracht ziehen.

  • Die Lebertransplantation ist derzeit die einzige kurative Therapie. Daher sollte man bei Patienten mit ALV umgehend mit einem Transplantationszentrum Kontakt aufnehmen.

 

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