Association of IGF-I and the IGF-I/IGFBP-3 Ratio with Plasma Aldosterone Levels in the General Population

A. Hannemann; H. Wallaschofski; R. Rettig; H. Völzke; S. Samietz; M. Nauck; M. Bidlingmaier; N. Friedrich

doi:10.1055/s-0031-1301300

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2012; 44(03): 228-233
DOI: 10.1055/s-0031-1301300

Humans, Clinical

Association of IGF-I and the IGF-I/IGFBP-3 Ratio with Plasma Aldosterone Levels in the General Population

A. Hannemann^*

¹Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

H. Wallaschofski^*

¹Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

R. Rettig

²Institute of Physiology, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

,

H. Völzke

³Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

,

S. Samietz

⁴Center of Oral Health, Policlinic of Prosthetic Dentistry, Gerodontology and Biomaterials, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

,

M. Nauck

¹Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

,

M. Bidlingmaier

⁵Medical Clinic Innenstadt, Ludwig-Maximilians-University Munich, Munich, Germany

,

N. Friedrich

¹Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University, Greifswald, Germany

› Author Affiliations

Abstract

Several studies in patients with acromegaly or growth hormone (GH) deficiency suggest a stimulatory effect of the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis on the renin-angiotensin-aldosterone system (RAAS). We analyzed the association of serum IGF-I with plasma aldosterone and the aldosterone-to-renin ratio in a large sample from the general population. In addition to serum IGF-I levels, we also considered the IGF-I-to-IGF binding protein (IGFBP)-3 ratio. A total of 1 504 men and 1 566 women aged 25–88 were selected from the first follow-up of the population-based Study of Health in Pomerania. Plasma aldosterone and renin concentrations, as well as serum IGF-I and IGFBP-3 levels were determined with immunoassays. Analyses of variance and linear regression analyses were performed. We found positive associations between serum IGF-I or the IGF-I/IGFBP-3 ratio with plasma aldosterone in women but not in men. Plasma aldosterone levels increased by 2.91 ng/l per IGF-I standard deviation (SD) and by 2.17 ng/l per IGF-I/IGFBP-3 SD. The associations remained significant after exclusion of subjects taking RAAS-altering medication and of subjects with serum IGF-I levels and aldosterone-to-renin ratios outside the reference range. We conclude that, serum IGF-I and the IGF-I/IGFBP-3 ratio are associated with plasma aldosterone levels in women but not in men from the general population.

Key words

growth hormone - insulin-like growth factor I - renin-angiotensin-aldosterone system

Full Text

References

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