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Planta Med 2012; 78(7): 730-736
DOI: 10.1055/s-0031-1298310
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Evaluation of Alkaloids and Isoflavonoids from the Australian Tree Erythrina vespertilio

Mehrdad Iranshahi1 , 2 , Hoan Vu2 , Ngoc Pham2 , Dusan Zencak2 , Paul Forster3 , Ronald J. Quinn2
  • 1Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  • 2Eskitis Institute, Griffith University, Brisbane, Australia
  • 3Queensland Herbarium, Department of Environment & Resource Management, Brisbane Botanic Gardens, Brisbane, Australia
Further Information

Publication History

received Nov. 26, 2011 revised February 1, 2012

accepted February 2, 2012

Publication Date:
21 February 2012 (online)

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Erratum for: Cytotoxic evaluation of alkaloids and isoflavonoids from the Australian tree Erythrina vespertilioPlanta Med 2012; 78(07): E20-E20
DOI: 10.1055/s-0031-1298401

Abstract

A new glucoalkaloid, vespertilioside, together with three known alkaloids, including 11-β-methoxyglucoerysovine, erysotrine, and hypaphorine, were isolated from the fruits of E. vespertilio Benth. In addition, three known isoflavonoids, including phaseollin, alpiniumisoflavone, and phaseollidin, were identified from the plant stems. The structures of compounds were determined by 1D/2D NMR and mass experiments. The cytotoxic activity of all compounds was evaluated against a metastatic prostate cancer cell line (PC3) and neonatal foreskin fibroblast (NFF) using a real-time label-free cell analyser. Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC50 = 8.83 ± 1.87 µM) and NFF (0.64 ± 0.37 µM) cell lines.

Key words

Erythrina vespertilio Benth. - Fabaceae - PC3 - prostate cancer - vespertilioside - xCELLigence

Supporting Information

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Mehrdad Iranshahi, PharmD, PhD, Associate Professor of Pharmacognosy

Department of Pharmacognosy
Pharmacy School
Mashhad University of Medical Sciences

Vakilabad Blvd.

Mashhad 91775-1365

Iran

Phone: +98 51 18 82 32 55

Fax: +98 51 18 82 32 51

Email: Iranshahim@mums.ac.ir