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Synthesis 2012(4): 541-546
DOI: 10.1055/s-0031-1290159
DOI: 10.1055/s-0031-1290159
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient Palladium-Catalyzed Cross-Coupling Reaction of Alkynyl Halides with Organoboronic Acids under Aerobic Conditions
Further Information
Received
12 November 2011
Publication Date:
16 January 2012 (online)
Publication History
Publication Date:
16 January 2012 (online)
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Abstract
Ligand-free palladium-catalyzed cross-coupling reaction of alkynyl halides with organoboronic acids under aerobic conditions has been developed. In the presence of bis(dibenzylideneacetone)palladium(0) and cesium carbonate, a variety of alkynyl halides (I, Br, and Cl) underwent the Suzuki-Miyaura cross-coupling reaction with organoboronic acids at room temperature to afford the corresponding unsymmetrical diarylalkynes in moderate to good yields. It is noteworthy that this is first report on the reaction of alkynyl chlorides with arylboronic acids.
Key words
palladium - alkynyl halides - organoboronic acids - cross-coupling reaction - alkynes
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