Direct Oxidative C-P Bond Formation of Indoles with Dialkyl Phosphites

Abstract

The direct phosphonation of indoles was developed. In this reaction, dialkyl phosphites and indoles were used as substrates, and the C-P bond was formed through oxidative coupling mediated by silver(I) acetate. Various indoles and different dialkyl phosphites were effective substrates for the reaction, and dialkylphosphoryl-substituted indoles were obtained in up to 71% yield.

indole - dialkyl phosphite - phosphonation - silver acetate - oxidative coupling

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The influence of metals and acids were tested and listed in the Supporting Information.

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