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DOI: 10.1055/s-0031-1283147
Decrease of Blood Lipids Induced by Shan-Zha (Fruit of Crataegus pinnatifida) is Mainly Related to an Increase of PPARα in Liver of Mice Fed High-Fat Diet
Publication History
received 01 June 2011
accepted 21 June 2011
Publication Date:
05 August 2011 (online)
![](https://www.thieme-connect.de/media/hmr/201109/lookinside/thumbnails/10.1055-s-0031-1283147-1.jpg)
Abstract
Hyperlipidemia is an important risk factor for cardiovascular diseases. Agents for the treatment of hyperlipidemia are well-developed in the clinic while PPARα is a target for lipid-lowering agents. Shan-Zha (Crataegus pinnatifida) is a traditional Chinese medicine used to increase digestion. Also, Shan-Zha fruit extract showed merit to improve obesity and hyperlipidemia in hamsters; however, the mechanism remained obscure. In the present study, hypertriglycemia and hypercholesterolemia were induced by high fat diet in C57BL/6 J male mice. Then, they were orally administered with Shan-Zha fruit extract at an effective dose of 250 mg/kg for 7 days. The liver was removed to estimate the expressions of PPARα and β-oxidation-related enzyme. Oral intake of Shan-Zha extract significantly improved hyperlipidemia in high fat diet-fed mice with an increase of PPARα expression in liver. Also, expression of PPARα-regulated β-oxidation-related enzymes was raised in liver by Shan-Zha extract. However, adipose tissue and others were not modified by this treatment of Shan-Zha fruit extract. Thus, Shan-Zha can increase the expression of PPARα to facilitate β-oxidation-related enzymes in liver for lipid degradation and blood lipid decrement. Also, this is the first report showing Shan-Zha fruit extract can influence liver to lower hyperlipidemia prior to the action in adipose tissue.
Key words
Shan-Zha - hyperlipidemia - peroxisome proliferator-activated receptor α - lipid oxidation - liver - mice* These authors contributed equally to this study.
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