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Synlett 2011(10): 1335-1339  
DOI: 10.1055/s-0030-1260578
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© Georg Thieme Verlag Stuttgart ˙ New York

Organocatalytic Enantioselective Halolactonizations: Strategies of Halogen Activation

Chong Kiat Tan, Ling Zhou, Ying-Yeung Yeung*
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
Fax: +6567791691; e-Mail: chmyyy@nus.edu.sg;
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Publication History

Received 07 February 2011
Publication Date:
26 May 2011 (online)

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Abstract

Halolactonization is a very useful organic reaction which has been applied in many syntheses in the past decades. In contrast, its asymmetric variant remains uncommon. Very recently, several organocatalytic halolactonization methodologies were developed which allows us to access a range of chiral halolactones.

Key words

asymmetric catalysis - cyclization - halogens - halogenation - lactones

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