The stereoselective syntheses of the naturally occurring α-pyrone
derivatives (+)-cryptofolione and (-)-cryptocaryalactone were
efficiently accomplished by using propane-1,3-diol as the starting
material. Keck allylation, Mitsunobu center inversion, and olefin
cross metathesis were used as the key steps. (-)-Cryptocaryalactone
was synthesized here for the first time.
total synthesis - lactones - natural products - Keck allylation - Mitsunobu center inversion - olefin
cross metathesis