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Synthesis 2011(16): 2561-2566  
DOI: 10.1055/s-0030-1260077
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart ˙ New York

Cobalt-Catalyzed Alkenylation of Thiazoles with Alkynes via C-H Bond Functionalization

Zhenhua Ding, Naohiko Yoshikai*
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
Fax: +65(6791)1961; e-Mail: nyoshikai@ntu.edu.sg;
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Publikationsverlauf

Received 15 March 2011
Publikationsdatum:
17. Juni 2011 (online)

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Abstract

A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions.

Key words

cobalt - C-H activation - heterocycles - hydroarylation - alkynes

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6

A small part of the present work was communicated in ref 2.