Synlett 2011(3): 425-429  
DOI: 10.1055/s-0030-1259511
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Design and Synthesis of Brazilin-Like Compounds

Chengxue Pan, Xianghui Zeng, Yifu Guan, Xiangliu Jiang, Liang Li, Hongbin Zhang*
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, P. R. of China
Fax: +86(871)5035538; e-Mail: zhanghb@ynu.edu.cn;
Further Information

Publication History

Received 20 October 2010
Publication Date:
25 January 2011 (online)

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Abstract

A general and flexible synthetic route, which leads to the synthesis of brazilin-like compounds, was developed. The aza-­brazilin derivatives show strong anticancer activities in MTT assay towards a number of human cancer cell lines including HT29, A549, HL60, and K562.