Synthesis of 2-Aminoindole-3-carboxylic
Acid Derivatives by the Copper(I) Iodide Catalyzed Reaction of N-(2-Iodophenyl)formamides with Malononitrile or
Cyanoacetates

Kazuhiro Kobayashi; Toshihide Komatsu; Yuki Yokoi; Hisatoshi Konishi

doi:10.1055/s-0030-1258422

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Synthesis 2011(5): 764-768
DOI: 10.1055/s-0030-1258422

PAPER

Synthesis of 2-Aminoindole-3-carboxylic Acid Derivatives by the Copper(I) Iodide Catalyzed Reaction of N-(2-Iodophenyl)formamides with Malononitrile or Cyanoacetates

Kazuhiro Kobayashi*, Toshihide Komatsu, Yuki Yokoi, Hisatoshi Konishi
Division of Applied Chemistry, Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan
Fax: +81(857)315263; e-Mail: kkoba@chem.tottori-u.ac.jp;

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Publication History

Received 9 November 2010
Publication Date:
03 February 2011 (online)

Abstract
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Abstract

An efficient method for the synthesis of 2-aminoindole-3-carbonitriles and 2-aminoindole-3-carboxylates by the reaction of N-(2-iodophenyl)formamides with malononitrile and cyanoacetates, respectively, in the presence of a catalytic amount of copper(I) iodide using potassium carbonate as a base is reported.

Key words

2-aminoindole-3-carboxylates - 2-aminoindole-3-carbonitriles - N-(2-iodophenyl)formamides - copper(I) iodide - coupling

References

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