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Synthesis 2011(5): 816-820  
DOI: 10.1055/s-0030-1258403
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(II) Oxide Catalyzed Ligand-Free Coupling Reaction of Heteroarenes with Bromoalkynes [¹]

Biswanath Das*, Gandolla Chinna Reddy, Penagaluri Balasubramanyam, N. Salvanna
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500607, India
Fax: +91(40)27160512; e-Mail: biswanathdas@yahoo.com;
Further Information

Publication History

Received 26 November 2010
Publication Date:
11 January 2011 (online)

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Abstract

The coupling reaction of imidazoles and pyrazoles with bromoacetylenes has efficiently been carried out under ligand-free conditions in the presence of copper(II) oxide as the catalyst using potassium hydroxide in 1,4-dioxane at 80 ˚C. The method is a simpler access to N-alk-1-ynyl- and/or N-(2-bromovinyl)-substituted heteroarenes.

Key words

coupling reaction - ligand-free conditions - copper(II) oxide - N-alkynylheteroarene - N-(2-bromovinyl)heteroarene

1

Part 217 in the series ‘Studies on novel synthetic methodologies’.

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1

Part 217 in the series ‘Studies on novel synthetic methodologies’.