Selective Monomethylation of
Quercetin

Zhong-hua Zhou; Zhuan Fang; Hui Jin; Yue Chen; Ling He

doi:10.1055/s-0030-1258310

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Synthesis 2010(23): 3980-3986
DOI: 10.1055/s-0030-1258310

PAPER

Selective Monomethylation of Quercetin

Zhong-hua Zhou^a, Zhuan Fang^a, Hui Jin^a, Yue Chen^b, Ling He*^a
^a Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, P. R. of China
^b Department of Nuclear Medicine Affiliated Hospital, Luzhou Medical College, No. 25 Taiping Street, Luzhou, Sichuan, 646000, P. R. of China
Fax: +86(28)85503365.; e-Mail: lhe2001@sina.com;

Further Information

Publication History

Received 24 June 2010
Publication Date:
21 October 2010 (online)

Abstract
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Abstract

Quercetin was monomethylated under mild conditions in moderate yields through selective deprotection. The combined effects of the protecting group and the heating mode on the reactivity were investigated. The presence of borax and the use of microwave irradiation significantly improved the yield and selectivity of alkylation.

Key words

alkylations - regioselectivity - methylation - heterocycles - quercetin

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