Synlett 2010(13): 1955-1958  
DOI: 10.1055/s-0030-1258135
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Selective Metalation of 4,6-Dibromoresorcinol Dimethyl Ether with LiTMP

George A. Kraus*, Insik Jeon, John Mengwasser, Aaron C. West, Theresa L. Windus
Department of Chemistry, Iowa State University, Ames, IA 50011, USA
Fax: +1(515)2940105; e-Mail: gakraus@iastate.edu;
Further Information

Publication History

Received 19 April 2010
Publication Date:
09 July 2010 (online)

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Abstract

4,6-Dibromoresorcinol dimethyl ether was selectively metalated at C-5 with lithium tetramethylpiperidide (LiTMP). A rationale for the selective metalation is proposed.