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DOI: 10.1055/s-0030-1255691
© Georg Thieme Verlag KG Stuttgart · New York
Giant atypical lymphoid hyperplasia of the colon
T.-Y. HuangMD, PhD
Division of Gastroenterology
Department of Internal Medicine
Tri-Service General Hospital
National Defense Medical Center
325 Cheng-Kung Road, Section 2
Neihu
Taipei 114
Taiwan
Fax: +866-2-8792-7138
Email: teinyu.chun@msa.hinet.net
Publication History
Publication Date:
15 September 2010 (online)
A 57-year-old woman with a history of acute myelogenous leukemia had received chemotherapy. Thereafter, she was relatively stable with complete remission.
After 8 years, the woman visited hospital for evaluation of intermittent abdominal fullness. Both physical examinations and laboratory studies were unremarkable. Double-contrast barium study and abdominal computed tomography disclosed a single mass of about 2 × 3 cm in the ascending colon ([Figs. 1] and [2]).
Colonoscopy confirmed a single polypoid mass in the ascending colon ([Fig. 3]).
Endoscopic mucosal resection was accordingly performed. Histopathological examination showed proliferation and aggregation of many atypical lymphoid cells, consistent with atypical lymphoid hyperplasia ([Fig. 4]).
The woman underwent colonoscopy 3 months later, which revealed that the mucosa of the lesion site had healed well.
Atypical lymphoid hyperplasia is a condition usually related to an underlying immune dysregulation, or a reactive change to various inciting antigens or irritating stimuli [1] [2] [3] [4]. To our knowledge, this is the first reported case of polyp-like atypical lymphoid hyperplasia in the colon; this may be considered a pre-lymphomatous state, and close follow-up is recommended [4] [5].
Competing interests: None
Endoscopy_UCTN_Code_CCL_1AD_2AC
#References
- 1 Crowson A N, Magro C M. Antidepressant therapy. A possible cause of atypical cutaneous lymphoid hyperplasia. Arch Dermatol. 1995; 131 925-929
- 2 Tanahashi T, Tatsumi Y, Sawai N. et al . Regression of atypical lymphoid hyperplasia after eradication of Helicobacter pylori. J Gastroenterol. 1997; 32 543-547
- 3 Viraben R, Lamant L, Brousset P. Losartan-associated atypical cutaneous lymphoid hyperplasia. Lancet. 1997; 350 1366
- 4 Krauss E, Konturek P, Maiss J. et al . Clinical significance of lymphoid hyperplasia of the lower gastrointestinal tract. Endoscopy. 2010; 42 334-337
- 5 Takano Y, Kato Y, Sugano H. Histopathological and immunohistochemical study of atypical lymphoid hyperplasia and benign lymphoid hyperplasia of the stomach. Jpn J Cancer Res. 1992; 83 288-293
T.-Y. HuangMD, PhD
Division of Gastroenterology
Department of Internal Medicine
Tri-Service General Hospital
National Defense Medical Center
325 Cheng-Kung Road, Section 2
Neihu
Taipei 114
Taiwan
Fax: +866-2-8792-7138
Email: teinyu.chun@msa.hinet.net
References
- 1 Crowson A N, Magro C M. Antidepressant therapy. A possible cause of atypical cutaneous lymphoid hyperplasia. Arch Dermatol. 1995; 131 925-929
- 2 Tanahashi T, Tatsumi Y, Sawai N. et al . Regression of atypical lymphoid hyperplasia after eradication of Helicobacter pylori. J Gastroenterol. 1997; 32 543-547
- 3 Viraben R, Lamant L, Brousset P. Losartan-associated atypical cutaneous lymphoid hyperplasia. Lancet. 1997; 350 1366
- 4 Krauss E, Konturek P, Maiss J. et al . Clinical significance of lymphoid hyperplasia of the lower gastrointestinal tract. Endoscopy. 2010; 42 334-337
- 5 Takano Y, Kato Y, Sugano H. Histopathological and immunohistochemical study of atypical lymphoid hyperplasia and benign lymphoid hyperplasia of the stomach. Jpn J Cancer Res. 1992; 83 288-293
T.-Y. HuangMD, PhD
Division of Gastroenterology
Department of Internal Medicine
Tri-Service General Hospital
National Defense Medical Center
325 Cheng-Kung Road, Section 2
Neihu
Taipei 114
Taiwan
Fax: +866-2-8792-7138
Email: teinyu.chun@msa.hinet.net