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Horm Metab Res 2010; 42(8): 543-552
DOI: 10.1055/s-0030-1252034
Review

© Georg Thieme Verlag KG Stuttgart · New York

The Impact of Endocrine Disruptors on Endocrine Targets

E. Diamanti-Kandarakis1 , E. Palioura1 , S. A. Kandarakis2 , M. Koutsilieris3
  • 1Endocrine Section, Third Department of Internal Medicine, Sotiria Hospital, University of Athens Medical School, Athens, Greece
  • 2Mount Sinai School of Medicine, New York, NY, USA
  • 3Laboratory of Experimental Physiology, University of Athens Medical School, Athens, Greece
Further Information

Publication History

received 08.11.2009

accepted 09.03.2010

Publication Date:
23 April 2010 (online)

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Abstract

Endocrine disruption represents one of the most controversial environmental issues of our époque. So far, many substances, both natural and artificial, have been recognized to interfere with endocrine signaling pathways. In intact laboratory animals, this interaction has been documented to generate adverse health outcomes by impairing normal functions. With regard to humans, evidence is limited and inconsistent to clearly establish a causal inference, however, accumulating data incriminate endocrine disrupting chemicals to reproductive disorders and disturbed thyroid homeostasis. Recently, as a result of animal models and preliminary human studies, a new area of interest has arisen concerning the implication of endocrine disruptors in the etiology of obesity and diabetes, the two major, life-threatening, epidemics of modern world. This article reviews the evidence linking endocrine disrupting chemicals to a broad spectrum of clinical perturbations from reproduction and thyroid to metabolic regulation.

Key words

endocrine disruptors - male reproduction - female reproduction - thyroid - obesity - diabetes

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E. Diamanti-Kandarakis

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