Subscribe to RSS
DOI: 10.1055/s-0030-1250148
© Georg Thieme Verlag KG Stuttgart · New York
Foreign Material Reaction to BioGlue® as a Possible Cause of Cardiac Tamponade
Publication History
received May 17, 2010
Publication Date:
25 November 2010 (online)
![](https://www.thieme-connect.de/media/thoracic/201008/lookinside/thumbnails/10.1055-s-0030-1250148-1.jpg)
Abstract
We describe the case of a 65-year-old female patient who underwent aortic valve reconstruction for aortic valve stenosis. During the operation, repair of a left ventricular laceration produced by a left ventricular vent was necessary. BioGlue® (CryoLife, Atlanta, GA, USA) and pledgeted sutures were used for repair. Pericardial effusion with signs of cardiac tamponade developed five months later. The patient was treated successfully by the removal of all foreign material and part of the BioGlue®. Microbiological findings were sterile. Histology showed a chronic granulomatous inflammatory response suggesting a foreign material reaction to BioGlue® as the cause of the effusion. Though all visible material was removed, the risk of pericardial effusion still persists as part of the BioGlue® remained within the ventricular wall.
Key words
Heart valve surgery - BioGlue® - pericardial effusion
References
- 1 Cavolli R, Kaya K, Elalmis A O. “Acute pseudo-pericardial tamponade”: the compression of the thoracal inferior vena cava – a case report. J Cardiothorac Surg. 2009; 4 9
- 2 Suzuki S, Imoto K, Uchida K, Takanaschi. Aortic root necrosis after surgical treatment using gelatin-resorcinol-formaldehyde (GRF) glue in patients with acute type A aortic dissection. Ann Thorac Cardiovasc Surg. 2006; 12 333-340
- 3 Ngaage D L, Edwards W D, Bell M R, Sundt T M. A cautionary note regarding long-term sequelae of biologic glue. Thoracic Cardiovasc Surg. 2005; 129 937-938
- 4 Cosseli J S, Bavaria J E, Fehrenbacher J, Stowe C L, Macheers S K, Gundry S R. Prospective randomized study of a protein-based tissue adhesive used as a hemostatic and structural adjunct in cardiac and vascular anastomotic repair procedures. J Am Coll surg. 2003; 197 243-253
- 5 Kazui T, Washiyama N, Bashar A H. Role of biologic glue repair of proximal aortic dissection in the development of early and midterm redissection of the aortic root. Ann Thorac Surg. 2001; 72 509-514
- 6 Katsumata T, Moorjani N, Vaccari G, Westaby S. Mediastinal false aneurysm after thoracic aortic surgery. Ann Thorac Surg. 2000; 70 547-552
- 7 Bringley J A, Gardner M A, Stafford E G. Late complications of tissue glues in aortic surgery. Ann Thorac Surg. 2000; 69 1764-1768
- 8 Martinelli L, Graffigna A, Guarnerio M, Bonmassari R, Disertori M. Coronary artery narrowing after aortic root reconstruction with resorcin-formalin glue. Ann Thorac Surg. 2000; 70 1701-1072
- 9 Tomizawa Y. Clinical benefits and risk analysis of topical haemostats: a review. J Artif Organs. 2005; 8 137-142
Dr. Jörg Babin-Ebell
Department of Cardiac Surgery
Cardiovascular Center Bad Neustadt
Salzburger Leite 1
97616 Bad Neustadt
Germany
Phone: +49 97 71 66 24 16
Fax: +49 97 71 65 12 19
Email: joerg.babin-ebell@web.de